Biogerontology

, Volume 11, Issue 5, pp 575–588

Mitochondrial function, mitochondrial DNA and ageing: a reappraisal

  • Giuseppe Passarino
  • Giuseppina Rose
  • Dina Bellizzi
SI: Frailty, Ageing and Inflammation

DOI: 10.1007/s10522-010-9294-3

Cite this article as:
Passarino, G., Rose, G. & Bellizzi, D. Biogerontology (2010) 11: 575. doi:10.1007/s10522-010-9294-3

Abstract

The impressive performance of the research in biology of mitochondrion has greatly improved our knowledge on the functions of this organelle and highlighted the influence its functioning has on numerous human phenotypes. In particular, many studies have focused on the involvement of mitochondrion function (and dysfunction) in human ageing. To date, the literature in this specific field of mitochondrial biology is so vast that it is often difficult to properly put new data and new findings in the right context. The present paper aims to review the findings of the last few years in order to outline a general framework to understand how mitochondria can affect ageing and how ageing affects mitochondria.

Keywords

MitochondrionmtDNAProgrammed deathHuman ageingAge related diseasesLongevityEpigenetic modificationsCybrids

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Giuseppe Passarino
    • 1
  • Giuseppina Rose
    • 1
  • Dina Bellizzi
    • 1
  1. 1.Department of Cell BiologyUniversity of CalabriaRendeItaly