Biogerontology

, Volume 11, Issue 5, pp 603–614

Targeting inflammation to slow or delay functional decline: where are we?

  • Andrea Corsonello
  • Sabrina Garasto
  • Angela Marie Abbatecola
  • Giuseppina Rose
  • Giuseppe Passarino
  • Bruno Mazzei
  • Luigi Pranno
  • Enrico Eugenio Guffanti
  • Silvia Bustacchini
  • Fabrizia Lattanzio
SI: Frailty

DOI: 10.1007/s10522-010-9289-0

Cite this article as:
Corsonello, A., Garasto, S., Abbatecola, A.M. et al. Biogerontology (2010) 11: 603. doi:10.1007/s10522-010-9289-0

Abstract

The role of inflammation in the pathophysiology of chronic age-related diseases is increasingly recognized, and inflammation could represent the common pathway linking diseases and disability. Thus, targeting inflammation could represent a useful strategy at preventing or delaying functional decline. In this paper we review recent evidence suggesting that selected drugs, such as statins, fibrates, angiotensin converting enzyme-inhibitors and angiotensin receptor blockers, and physical exercise may be able to contrast functional decline by blunting inflammation. Results from randomized trials investigating the effects of physical activity programs on inflammation and functional decline is still limited, and further investigations are warranted.

Keywords

InflammationFunctional declineChronic diseasesAgingStatinsAngiotensin-converting enzyme-inhibitorsAngiotensin receptor blockersPhysical exercise

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Andrea Corsonello
    • 1
  • Sabrina Garasto
    • 1
  • Angela Marie Abbatecola
    • 2
  • Giuseppina Rose
    • 3
  • Giuseppe Passarino
    • 3
  • Bruno Mazzei
    • 4
  • Luigi Pranno
    • 4
  • Enrico Eugenio Guffanti
    • 5
  • Silvia Bustacchini
    • 2
  • Fabrizia Lattanzio
    • 2
  1. 1.Unit of Geriatric Pharmacoepidemiology, Research Hospital of CosenzaItalian National Research Centre on Aging (INRCA)CosenzaItaly
  2. 2.Italian National Research Centre on Aging (INRCA), Scientific DirectionAnconaItaly
  3. 3.Department of Cell BiologyUniversity of CalabriaRendeItaly
  4. 4.Unit of Geriatric Medicine and Stroke Unit, Research Hospital of CosenzaItalian National Research Centre on Aging (INRCA)CosenzaItaly
  5. 5.Unit of Pulmonary Rehabilitation, Research Hospital of CasatenovoItalian National Research Centre on Aging (INRCA)CasatenovoItaly