Research Article

Biogerontology

, Volume 10, Issue 5, pp 565-578

Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43

  • Kerstin PietschAffiliated withLaboratory of Freshwater and Stress Ecology, Department of Biology, Humboldt-Universität zu Berlin Email author 
  • , Nadine SaulAffiliated withLaboratory of Freshwater and Stress Ecology, Department of Biology, Humboldt-Universität zu Berlin
  • , Ralph MenzelAffiliated withLaboratory of Freshwater and Stress Ecology, Department of Biology, Humboldt-Universität zu Berlin
  • , Stephen R. StürzenbaumAffiliated withPharmaceutical Science Division, School of Biomedical & Health Sciences, King’s College London
  • , Christian E. W. SteinbergAffiliated withLaboratory of Freshwater and Stress Ecology, Department of Biology, Humboldt-Universität zu Berlin

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Abstract

The nematode Caenorhabditis elegans responds to flavonoid-rich diets with improved health and longevity. The precise mechanism(s) responsible for this remains to be identified, but is believed to be linked to the highly antioxidative properties of flavonoids. This study provides a dissection of lifespan modulation by the flavonoid quercetin. In detail, quercetin was shown not to act as a simple antimicrobial agent or exclusively via radical scavenging capacities. Likewise, lifespan extension had no effect on reproduction and body length. Furthermore, neither a caloric restriction mimetic nor a sirtuin (sir-2.1) dependence was identified as a likely mode of action. However, four genes were pinpointed to be required for the quercetin derived lifespan extension, namely age-1, daf-2, unc-43 and sek-1. The latter two have, to date, not been linked to quercetin-mediated lifespan extension.

Keywords

C. elegans Quercetin Lifespan age-1 daf-2 unc-43 sek-1