Caloric restriction and human longevity: what can we learn from the Okinawans?
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Caloric (or dietary) restriction (CR) extends lifespan and lowers risk for age associated diseases in a phylogenetically diverse group of species. Whether prolonged CR increases average or maximum lifespan or promotes a more youthful physiology in humans at advanced ages is not yet known. However, available epidemiological evidence indicates that CR may already have contributed to an extension of average and maximum life span in one human population and appears to have lowered risk for age associated chronic diseases in other human populations. We review the human studies in the context of a special human population, older Okinawans, who appear to have undergone a mild form of prolonged CR for about half their adult lives.
- Caloric restriction and human longevity: what can we learn from the Okinawans?
Volume 7, Issue 3 , pp 173-177
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- Springer Netherlands
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- Caloric restriction
- Maximum life span
- Healthy aging
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- Author Affiliations
- 1. College of Nursing, Okinawa Prefectural University, 1-24-1 Yogi, Naha, Okinawa, 902-0076, Japan
- 2. Pacific Health Research Institute, 846 South Hotel Street, Suite 301, Honolulu, HI, 96813, USA
- 3. Departments of Geriatric Medicine and Medicine, John A. Burns School of Medicine, University of Hawaii, 1356 Lusitana Street, 7F, Honolulu, HI, 96813, USA
- 4. Faculty of Medicine, University of the Ryukyus, Department of Environmental and Prevantive Medicine, 207 Vehara, Nishihara, Okinawa, 903-0215, Japan
- 5. Faculty of Human Welfare, Okinawa International University,, 2-6-1 Ginowan, Ginowan City, Okinawa, 901-2701, Japan