Research Article


, Volume 6, Issue 4, pp 255-260

First online:

A Cross-sectional Study of Homocysteine-, NO-levels, and CT-findings in Alzheimer Dementia, Vascular Dementia and Controls

  • Marcella FolinAffiliated withDepartments of Biology, University of Padua Email author 
  • , Silvia BaigueraAffiliated withDepartments of Biology, University of Padua
  • , Maurizio GallucciAffiliated withCa’ Foncello Hospital
  • , Maria Teresa ConconiAffiliated withPharmaceutical Sciences, University of Padua
  • , Rosa Di LiddoAffiliated withPharmaceutical Sciences, University of Padua
  • , Andrea ZanardoAffiliated withClinical Chemistry Laboratory, Ca’ Foncello Hospital
  • , Pier Paolo ParnigottoAffiliated withPharmaceutical Sciences, University of Padua

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Repetitive measurement with neuroimaging techniques could be useful instruments permitting to differentiate between Alzheimer disease (AD) and vascular dementia (VD). The major genetic risk factor for the development of late-onset AD is the allele ε4 of the apolipoprotein E (ApoE). Moreover nitric oxide (NO) and homocysteine (Hcy) seems to be correlated with the degree of cognitive impairment in demented subjects. The aim of this study was to investigate the association between serum NO and Hcy levels, global brain atrophy and brain vascular lesion in AD and VD patients. We report that high plasma levels of homocysteine resulted associated with AD and VD, suggesting that in AD elevated plasma Hcy might be a consequence of concomitant vascular dementia. Otherwise, plasma NO levels were not significantly different in any of the groups. Moreover, neuroimaging measures of vascular lesion level could be of usefulness to differentiate between AD and VD.


Alzheimer’s disease apolipoprotein E cognitive impairment homocysteine neuroimaging nitric oxide vascular dementia