Behavior Genetics

, Volume 41, Issue 4, pp 557–564

No Association of the YWHAE Gene with Schizophrenia, Major Depressive Disorder or Bipolar Disorder in the Han Chinese Population

  • Jie Liu
  • Guoquan Zhou
  • Weidong Ji
  • Junyan Li
  • Tao Li
  • Ti Wang
  • You Li
  • Zhen Zeng
  • Zhiwei Hu
  • Linqing Zheng
  • Jue Ji
  • Yang Wang
  • Zhiyun Wei
  • Guoyin Feng
  • Lin He
  • Yongyong Shi
Original Research

DOI: 10.1007/s10519-010-9426-1

Cite this article as:
Liu, J., Zhou, G., Ji, W. et al. Behav Genet (2011) 41: 557. doi:10.1007/s10519-010-9426-1

Abstract

YWHAE is a gene encoding 14-3-3epsilon, which is highly conserved across species, from bacteria to humans, and binds to phosphoserine/phosphothreonine motifs in a sequence-specific manner. YWHAE has been reported to be associated with schizophrenia in a study based on the Japanese population. Here, we conducted a genetic association analysis between common SNPs in the YWHAE gene and psychiatric diseases including schizophrenia, major depressive disorder and bipolar disorder in Han Chinese samples (1140 schizophrenia cases, 1140 major depressive disorder cases, 1140 bipolar disorder cases and 1140 normal controls). We studied 11 SNPs, seven of which had previously been reported as significant, in YWHAE. No association was found with schizophrenia, major depressive disorder or bipolar disorder. Considering the size of our sample sets (power > 90%), our results suggest that the YWHAE does not play a major role in schizophrenia, major depressive disorder or bipolar disorder in the Han Chinese population.

Keywords

YWHAE geneSchizophreniaMajor depressive disorderBipolar disorder

Supplementary material

10519_2010_9426_MOESM1_ESM.docx (132 kb)
(DOCX 132 kb)

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jie Liu
    • 1
    • 5
  • Guoquan Zhou
    • 1
    • 5
  • Weidong Ji
    • 1
    • 5
  • Junyan Li
    • 1
  • Tao Li
    • 1
  • Ti Wang
    • 1
  • You Li
    • 1
  • Zhen Zeng
    • 1
  • Zhiwei Hu
    • 1
  • Linqing Zheng
    • 1
  • Jue Ji
    • 1
  • Yang Wang
    • 1
  • Zhiyun Wei
    • 1
  • Guoyin Feng
    • 2
  • Lin He
    • 1
    • 3
    • 4
  • Yongyong Shi
    • 1
    • 5
    • 6
  1. 1.Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of EducationShanghai Jiao Tong UniversityShanghaiPeople’s Republic of China
  2. 2.Shanghai Institute of Mental HealthShanghaiPeople’s Republic of China
  3. 3.Institute for Nutritional Sciences, Shanghai Institutes of Biological SciencesChinese Academy of SciencesShanghaiPeople’s Republic of China
  4. 4.Institutes of Biomedical SciencesFudan UniversityShanghaiPeople’s Republic of China
  5. 5.Bio-X Center Affiliated Changning Mental Health CenterShanghai Jiao Tong UniversityShanghaiPeople’s Republic of China
  6. 6.Institute of Neuropsychiatric Science and Systems Biological MedicineChangning Mental Health Center, The Bio-X Center HospitalShanghaiPeople’s Republic of China