Behavior Genetics

, Volume 40, Issue 2, pp 125–134

A Bivariate Twin Study of Regional Brain Volumes and Verbal and Nonverbal Intellectual Skills During Childhood and Adolescence

Authors

    • Child Psychiatry Branch, National Institute of Mental HealthNational Institutes of Health
  • Nancy Raitano Lee
    • Child Psychiatry Branch, National Institute of Mental HealthNational Institutes of Health
  • Elizabeth C. Prom-Wormley
    • Virginia Institute for Psychiatric and Behavioral GeneticsVirginia Commonwealth University
  • Sarah E. Medland
    • Virginia Institute for Psychiatric and Behavioral GeneticsVirginia Commonwealth University
    • Genetic Epidemiology UnitQueensland Institute of Medical Research
  • Rhoshel K. Lenroot
    • Child Psychiatry Branch, National Institute of Mental HealthNational Institutes of Health
  • Liv S. Clasen
    • Child Psychiatry Branch, National Institute of Mental HealthNational Institutes of Health
  • James E. Schmitt
    • Virginia Institute for Psychiatric and Behavioral GeneticsVirginia Commonwealth University
  • Michael C. Neale
    • Virginia Institute for Psychiatric and Behavioral GeneticsVirginia Commonwealth University
  • Jay N. Giedd
    • Child Psychiatry Branch, National Institute of Mental HealthNational Institutes of Health
Original Research

DOI: 10.1007/s10519-009-9329-1

Cite this article as:
Wallace, G.L., Lee, N.R., Prom-Wormley, E.C. et al. Behav Genet (2010) 40: 125. doi:10.1007/s10519-009-9329-1

Abstract

Twin studies indicate that both intelligence and brain structure are moderately to highly heritable. Recent bivariate studies of adult twins also suggest that intelligence and brain morphometry are influenced by shared genetic factors. The current study examines shared genetic and environmental factors between brain morphometry and intelligence in a sample of children and adolescents (twins, twin siblings, and singletons; n = 649, ages 4–19). To extend previous studies, brain morphometric data were parsed into subregions (lobar gray/white matter volumes, caudate nucleus, lateral ventricles) and intelligence into verbal and nonverbal skills (Wechsler Vocabulary and Block Design subtests). Phenotypic relationships between brain volumes and intelligence were small. Verbal skills shared unique environmental effects with gray matter volumes while nonverbal skills shared genetic effects with both global and regional gray and white matter. These results suggest that distinct mechanisms contribute to the small phenotypic relationships between brain volumes and verbal versus nonverbal intelligence.

Keywords

TwinMagnetic resonance imagingBrainIntelligenceVerbalNonverbal

Copyright information

© US Government  2010