Born to be Happy? The Etiology of Subjective Well-Being
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- Bartels, M. & Boomsma, D.I. Behav Genet (2009) 39: 605. doi:10.1007/s10519-009-9294-8
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Subjective Wellbeing (SWB) can be assessed with distinct measures that have been hypothesized to represent different domains of SWB. The current study assessed SWB with four different measures in a genetically informative sample of adolescent twins and their siblings aged 13–28 years (N = 5,024 subjects from 2,157 families). Multivariate genetic modeling was applied to the data to explore the etiology of individual differences in SWB measures and the association among them. Developmental trends and sex differences were examined for mean levels and the variance-covariance structure. Mean SWB levels were equal in men and women. A small negative effect of age on mean levels of SWB was found. Individual differences in SWB were accounted for by additive and non-additive genetic influences, and non-shared environment. The broad-sense heritabilities were estimated between 40 and 50%. The clustering of the four different measures (quality of life in general, satisfaction with life, quality of life at present, and subjective happiness) was explained by an underlying additive genetic factor and an underlying non-additive genetic factor. The effect of these latent genetic factors on the phenotypes was not moderated by either age or sex.
KeywordsSubjective wellbeing Happiness Multivariate modeling Heritability Twin-sibling design
Subjective Wellbeing (SWB) can be assessed with a series of measures representing distinct concepts such as satisfaction with life, happiness, quality of life, and life fulfillment. These concepts represent the affective (Diener and Emmons 1984) and cognitive evaluation (Andrews and Withey 1976) of one’s life. SWB has been defined as the total sum of the cognitive and emotional reactions that people experience when they compare what they have and do in life with their aspirations, needs, and other expectations (Calman 1984). This definition is in line with the description given by Diener et al. (1999) that explains SWB as a broad category of phenomena that includes people’s emotional responses, domain satisfaction, and global judgments of life satisfaction.
Over the years several attempts have been undertaken to evaluate the specificity and overlap of the concepts that fall under the umbrella of SWB, with most research done on quality of life and satisfaction with life. These concepts have, for example, been of importance for the evaluation of the quality and outcome of health care. Several analyses suggest that quality of life and satisfaction with life can be interchangeably used (Dijkers 2005, 2007; Ferrans 1996; Meeberg 1993; Zhan 1992), but should be contrasted to happiness, which is a more temporary and short-term affective state (Moons et al. 2006). A major distinction between satisfaction with life and quality of life versus happiness is that happiness fluctuates significantly across time and may change from day to day, while satisfaction with life and quality of life have a larger degree of consistency (Diener et al. 1997). This aspect of time fluctuation is also captured in the time-sequential framework of subjective well-being as proposed by Kim-Prieto, Diener (2005). They suggest that distinct measures of SWB are interrelated over time, starting with events and circumstances that lead to emotional reactions and memory of emotions, and ending with global judgments. There is further evidence that multiple concepts of wellbeing are distinct. Andrews and Withey (1976) found, for example, that life satisfaction formed a separate factor form positive affect and this finding was replicated 20 years later (Lucas et al. 1996). Research on the overlap of SWB and personality showed that distinct personality traits map onto separate components of SWB (Larsen and Ketelaar 1991). Genetic variance underlying individual differences in SWB is responsible for individual differences in Neuroticism, Extraversion, and, to a lesser extent, Conscientiousness (Weiss et al. 2008). The latter study also found evidence for a general genetic factor underlying individual differences in the five personality domains and subjective well-being and the authors hypothesize that personality acts as a kind of affective reserve that might be relevant to stability and change of the SWB set point over time.
Often, distinct measures, such as satisfaction with life, happiness and quality of life, are interchangeably used, even within studies, to provide information on SWB. For example, quality of life is often used to assess SWB in large-scale world-wide investigations in different countries, such as the Health Behavior in School aged Children study (HBSC; WHO, 2008) and the large scale UNICEF study (Innocenti Research Centre 2007). In these projects participants were asked to rate quality of life, using the 10-step Cantril Ladder (Cantril 1965). The top of the ladder indicates the best possible life, and the bottom, the worst possible life. In the HBSC study high life satisfaction, with a score of “6” or more on the 10-point ladder, was common among young people. Between ages 11 and 15, there was a significant decline in levels of life satisfaction with a more pronounced effect in girls than boys. Boys reported high life satisfaction more often than girls at ages 13 and 15 (Currie et al. 2008). In parallel, UNICEF reported that the great majority of young people growing up in OECD (organization for economic co-operation and development) countries scored themselves above the midpoint on the ‘life satisfaction ladder’ and life satisfaction decreased between the ages of 11 and 15, particularly girls. More specifically, the Netherlands head the table of overall well-being, and the United States and United Kingdom close it. Although, mean differences in well-being between different countries are impressive, the variance between countries actually is substantially smaller than the variance within countries. The causes of these individual differences in well-being have been described in six studies and knowledge about the etiology of SWB could provide new opportunities to develop prevention and intervention programs for those who are less happy and satisfied with their life. If happiness of these people could be slightly increased it could result in better mental and physical health, more effective coping and in the longer end longevity (Tugade and Fredrickson 2004; Cohn et al. 2009).
The six studies that investigated the etiology of SWB showed significant heritability estimates in the range of 40–50%. The remaining variance was accounted for by environmental influences unique to an individual (Tellegen et al. 1988; Lykken and Tellegen 1996; Røysamb et al. 2002, 2003; Stubbe et al. 2005; Nes et al. 2006). The study by Tellegen et al. (1988) used the well-being scale of the Multidimensional Personality Questionnaire, and reported non-additive genetic effects. These findings were replicated by Lykken and Tellegen (1996). Røysamb et al. (2002) employed the short version of the subjective well-being scale (Moum et al. 1990) and found no evidence for non-additive genetic effects. This study and a study with a larger sample conducted 1 year later (Røysamb et al. 2003) presented quantitative sex-differences, with somewhat larger heritability estimates for women (54%) than for men (46%). The most recent study (Nes et al. 2006) with a partly overlapping dataset found heritability estimates 42–56% and reported sex-specific additive genetic and nonshared environmental effects. The longitudinal design of this last study enabled investigation of underlying sources of stability and found a 6 year stability of SWB that was mainly attributable to stable additive genetic factors (Nes et al. 2006). Finally, a study by Stubbe et al. (2005), in a large twin-sibling sample reported a broad sense heritability of 38% for satisfaction with life, measured with the satisfaction with life scale (Diener et al. 1985). Non-additive genetic effects explained almost all of the genetic influences. No sex-differences were found.
The studies on subjective wellbeing (Tellegen et al. 1988; Lykken and Tellegen 1996; Røysamb et al. 2002, 2003; Nes et al. 2006), or on satisfaction with life (Stubbe et al. 2005) have not addressed question if the distinct constructs of well-being (satisfaction with life, subjective happiness, and quality of life) have different etiologies, or whether they are just distinct descriptions of a single latent SWB concept. Genetic influences have been reported for both satisfaction with life as well as subjective wellbeing and based on the rather high phenotypic correlation between the constructs, a high genetic overlap might be expected as well.
What are the causes of individual differences for each of the four measures of SWB?
Are there quantitative and/or qualitative sex differences in the genetic architecture of these measures?
Is there a change in the magnitude of genetic and environmental factors from age 12 to age 23?
To what extent are the four measures associated?
Are associations among measures explained by common genetic or common environmental influences?
Participants were registered at birth with the Netherlands Twin Registry (NTR), established by the Department of Biological Psychology at the VU University in Amsterdam (Boomsma et al. 2006; Bartels et al. 2007). Between registration and adolescence information on childhood emotional and behavioral problems was collected from parental and teacher reports. When the twin pair reached the age of 13 parents were asked for informed consent to contact the adolescent twins and their non-twin siblings (aged 12 years and older). Next a self-report survey was collected in adolescence in twins (mean age: 15.55, SD = 1.5) and siblings (mean age: 17.09, SD = 3.1). The sample for this study consisted of 2,015 first-born twins, 2,037 second-born twins, 438 singleton brothers and 534 sisters (N = 5,024 individuals; 45% male) from 2,157 families. The overall family response rate was 56.1%.
A maximum of two siblings (one brother and one sister) per family were included in the analyses. A few families (n = 20) had data on more than one sibling of the same sex. From these families data from the sibling closest in age to the twin was selected for analyses. Zygosity was determined for 461 same-sex twin pairs by DNA analysis or blood group polymorphisms. For all other same-sex twin pairs, zygosity was determined by discriminant analysis, using longitudinal questionnaire items from the previously collected parental report. Agreement between zygosity assignment by the replies to the longitudinal questionnaire and zygosity determined by DNA markers/blood typing was around 93% (Rietveld et al. 2000). The sample consisted of 321 complete MZM twin pairs, 264 complete DZM pairs, 449 complete MZF pairs, 326 complete DZF pairs, 263 male-female pairs and 240 female-male pairs, and 326 twins of incomplete pairs.
Quality of life in general (QLg) was assessed with the Cantril Ladder (Cantril 1965). It has ten steps: the top indicates the best possible life, and the bottom the worst possible life. Participants were asked to indicate the step of the ladder at which they place their lives in general.
Satisfaction with life (SAT) was assessed with the five item Satisfaction with Life Scale (Diener et al. 1985). Example items are: “My life is going more or less as I wished” and “I’m satisfied with life.” Participants were asked to answer at a 7-point likert scale with 0 indicating strongly disagree and 7 indicating strongly agree.
Quality of life at the moment of measurement (QLp) was also assessed with the Cantril Ladder (Cantril 1965). Participants were asked to indicate the step of the ladder at which they would place their lives at the moment.
Subjective Happiness (HAP) was assessed with the 4-item Subjective Happiness Scale (Lyubomirsky and Lepper 1999). On a 7-point likert scale, adolescents had to indicate whether they agreed or disagreed with statements like: “On the whole I’m a happy person” and “On the whole, I’m not very happy”.
Genetic structural equation modeling in Mx (Neale et al. 2006) was used with the raw-data Maximum Likelihood procedure for estimation of parameters. Nested submodels were compared by hierarchic χ2 tests. The χ2 statistic is computed by subtracting −2LL (log-likelihood) for the full model from that for a reduced model (χ2 = −2LL1−(−2LL0)). Given that the reduced model is correct, this statistic is χ2 distributed with degrees of freedom (df) equal to the difference in the number of parameters estimated in the two models (Δdf = df1 − df0). In addition to the χ2 test statistic, Akaike’s Information Criterion (AIC = χ2 − 2df) was computed. The lower the AIC, the better the fit of the model to the observed data.
Descriptive statistics and correlations
First, for each measure means, variances, and the effects of sex and age on the means were estimated. A covariance matrix was estimated conditional on zygosity and sex, which provides information on covariances among measures and family members, to gain insight into the sources of individual differences and the underlying sources of overlap between the distinct measures of SWB.
Monozygotic (MZ) twins derive from a single zygote and are (nearly always) genetically identical. Less than perfect MZ twin correlations (rMZ < 1) indicate environmental effects that are not shared between children growing up in the same family. Dizygotic (DZ) twins develop from two zygotes and, like non-twin siblings, share on average 50% of their segregating genes. A higher resemblance of MZ versus DZ twin pairs and twin-sibling correlations therefore may reflect the higher genetic similarity and indicates genetic effects. The design allows the estimation of environmental influences common to or shared by twins and siblings growing up in the same family. These shared environmental influences are implied if the resemblance between twin and sibling pairs exceeds the resemblance expected on the basis of quantitative genetic theory. When the DZ correlation is higher than the twin-sibling correlation, a specific environment might exist which is shared by twins but not by non-twin siblings (Eaves et al. 1999).
Multivariate data of twins and siblings provide the opportunity to decompose the variance of a trait as well as the covariance among traits into additive and non-additive genetic, shared environmental, and nonshared environmental components. Additive genetic factors (A) represent the sum of the effects of alleles over all loci that influence the trait. Non-additive genetic factors concern interactions between alleles, which can occur in two ways. Non-additive genetic factors (D) represent interaction between alleles at the same locus (dominance) or interaction between alleles at the different loci (epistasis). Shared environmental factors (C) are the part of the variance that is shared by members of family and nonshared environmental factors (E) is the part of the total variance that is unique to a certain individual. Non-additive genetic effect and shared environmental effects are confounded in the classical twin (sibling) design and are therefore estimated in separate models. Based on the literature and the correlations we from hereon continue with models considering additive genetic, non-additive genetic, and nonshared environmental effects only.
Age and sex effects
Correlated factor, common pathway, and independent pathway models
Descriptive statistics and correlations
No significant differences in means were found between males and females (χ42 = 0, P = 1.0). The small negative age effect on the means was significant (χ42 = 40.45, P = .00), indicating that adolescents scored higher on subjective well-being than young adults (QLg: −.04; QLp:−.06 SAT: −.11; HAP −.08). Grand means (uncorrected for age) for the four measures of SWB were estimated at 8.3 for QLg, 28.3 for SAT, 8.9 for QLp, and 23.1 for HAP. Sex differences in variance were found (χ502 = 83.14, P = .002). However, no zygosity/sibling effect on variances was observed (χ602 = 56.53, P = .6). For all 4 measures, covariances were equal for DZ twin and twin-sib pairs within sex (χ402 = 47.96, P = .18).
Maximum likelihood estimates of phenotypic correlations among four measures of subjective well being (correlations in men above the diagonal and correlations in women below the diagonal)
Twin-sib correlations and cross-correlations. On the diagonal MZ/DZ-sib correlations are given, off-diagonal gives the MZ cross-correlations above and DZ-SIB cross-correlations below the diagonal
Age and sex effects- the moderator model
Model fitting started with an ADE model for all four measures of SWB. Age moderation was not significant for additive genetic, non-additive genetic and nonshared environmental effect for any of the SWB measures (all p-values > .05). Sex moderation was only significant for additive genetic influences on QLg (P = .011) and nonshared environmental influences on HAP (P = .023).
Correlated factor, common pathway, and independent pathway models
Multivariate genetic model fitting: fit statistics
2. A correlated factors
3. D correlated factors
4. A & D correlated factors
5. Common pathway model + specifics
6. A independent pathway + specific
7. D independent pathway + specific
8. A & D independent pathway + specific
9. No A specifics
10. No D specifics
11. No D specifics for SAT and QLp
12. E independent pathway + specific
13. E correlated factors
14. A & D independent pathway; no A specific D specifics for Qlg & HAP; E Cholesky
Standardized estimates (95% CI) for additive genetic, non-additive genetic, and nonshared environmental influences on the four measures of SWB and their covariance based on the best fitting model
.25 (.13/.12)* (.23–.25)
.09 (.00 –.13)
.26 (.19/.07)* (.11–.32)
There are several constructs reflecting subjective wellbeing. One way to distinguish the different constructs is along the lines of cognitive versus emotionally driven subjective well-being. Another way to distinguish them is along a time line in which ad hoc feelings of well-being are distinguished from feeling well in general or over a longer time frame. Although discriminate validity between the cognitive component and the emotional component has been established (Lucas et al. 1996) and a time-sequential framework has been suggested (Kim-Prieto et al. 2005), no study focused on the underlying source of covariance of often used measures of well-being.
In the current study causes of individual differences of four measures of SWB and the underlying sources of overlap were investigated. We tested distinct multivariate models to gain optimal insight into the causes of phenotypic clustering.
The best fitting model included an independent pathway specification for A and D, and a cholesky decomposition for E. This finding in combination with the absence of measurement specific influences of additive genetic effects and only significant measurement specific non-additive genetic effects for Quality of life in general and Happiness, indicates that underlying sets of genes are responsible for the moderate to high phenotypic correlations. The implication of this finding is that distinct measures of SWB are not distinct at the genetic level. All four measures, used in this study, load on similar sets of genes. This makes comparison of different studies and collaboration by combining distinct datasets feasible.
We found that genetic and nonshared environmental influences explain individual differences in QLg, QLp, SAT, and HAP. Broad heritabilities (A + D) are in the range of 36–50%. Significant non-additive genetic influences are found for all four measures, accounting for up most 38% of the variance. Heritability estimates are in line with the findings of previous studies (Tellegen et al. 1988; Lykken and Tellegen 1996; Røysamb et al. 2002, 2003; Stubbe et al. 2005; Nes et al. 2006). Covariance between the four measures is mainly accounted for by additive and non-additive effects. Recently, doubts have been raised concerning the power to detect non-additive genetic effects and the possibility to distinguish these from sibling interaction/contrast effects in previous studies on SWB (Weiss et al. 2008). The current multivariate study, with a twin-sibling design, a sample size of over 5,000 individuals, and no evidence for variance differences between MZ and DZ twins, provides convincing evidence for the importance of non-additive genetic effects in explaining individual differences in SWB (Posthuma and Boomsma 2000; Rietveld et al. 2003). Sex-differences are not of importance for either mean levels of SWB or for the genetic architecture. The absence of sex-specific genetic influences and the absence of age effects on the genetic architecture imply that for purposes of identifying and quantifying genetic and environmental influences on SWB sex and age are no matter of concern in adolescents and young adults. An effect of age on mean levels of SWB is found in our data spanning the age range from 12 to 23. We find the expected small but significant negative effect of age on mean levels of SWB.
Our results may be of importance to psychology and psychiatry. The finding of the genetic overlap between the different measures of wellbeing fosters the field of positive psychology and its research. One of the growing topics within this field is the cross-cultural comparison of wellbeing (Diener et al. 2003). Our finding that a relative culture free measure, such as the Cantril ladder, shows complete genetic overlap with more culturally sensitive measures of life satisfaction, indicates that for international comparison simple measures could be used. Furthermore, studies that so far collected distinct measures of SWB can still be compared, based on the fact the distinct measures all load on a similar genetic factor, and thus represent biological overlapping constructs. Finally, our findings indicate that over half of the variance in SWB is accounted for by nonshared environmental influences. So, although it can be assumed that each individual has its, probably genetically determined, setpoint of SWB (Lykken 1999), influences of environmental factors unique to each individual are important. If we are able not only to quantify but also indentify these effects, we will learn what environmental factors make some people happier than others. A next step will be to use this information in the development of happiness intervention programs or psychopathology prevention programs. Obvious factors of importance are income (Clark et al. 2008; Stutzer 2004), education (Blanchflower and Oswald 2004; Bukenya et al. 2003), unemployment (Clark and Oswald 1994; Lucas et al. 2004), religion (Ciarrochi and Deneke 2005; Francis and Kaldor 2002), exercise (Stubbe et al. 2007; Biddle and Ekkekakis 2005), marriage (Brown 2000), friendship (Lelkes 2006; Pichler 2006), and economic/political environment (Kahneman et al. 2004; Di Tella et al. 2003), but overall effect sizes are found to be small, explaining 16–30% of the variance in SWB, leaving the largest part of environmental variance in SWB unexplained. While some of the examples do not fit the age group studied in the current manuscript an overall explanation for the small effects on the variance, could be the fact that no study to date has allowed for gene-environment interplay when studying SWB, with the possibility that part of the environment will actually turn out to represent gene-environment interaction. For example it has been found that religious people report greater happiness than their irreligious counterparts (e.g. Ciarrochi and Deneke 2005). Religion has also been studied in the context of gene-environment interaction. Boomsma et al. (1999) found that religious upbringing significantly moderated the magnitude of genetic influences on the personality trait of behavioral disinhibition, with a smaller estimate of the importance of genetic influences for those who were raised religiously than those who were not raised religiously. Furthermore, higher heritabilities for the risk of alcohol use initiation in females without a religious upbringing compared to females with a religious upbringing have been reported (Koopmans et al. 1999). In this context, the question rises if religious upbringing modifies the genetic architecture of SWB. So, future research should focus on the complex interplay between genes and environment, without being concerned about which measure of SWB should be used.
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