Original Research

Behavior Genetics

, Volume 39, Issue 5, pp 513-523

First online:

No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples

  • Penelope A. LindAffiliated withGenetic Epidemiology Unit, PO Royal Brisbane Hospital Email author 
  • , Michelle LucianoAffiliated withGenetic Epidemiology Unit, PO Royal Brisbane HospitalDepartment of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
  • , Michael A. HoranAffiliated withClinical Gerontology, Hope Hospital, University of Manchester
  • , Riccardo E. MarioniAffiliated withDivision of Community Health Sciences, University of Edinburgh
  • , Margaret J. WrightAffiliated withGenetic Epidemiology Unit, PO Royal Brisbane Hospital
  • , Timothy C. BatesAffiliated withDepartment of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
  • , Patrick RabbittAffiliated withAge and Cognitive Performance Research Centre, University of Manchester
  • , Sarah E. HarrisAffiliated withDepartment of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of EdinburghCentre for Cognitive Ageing and Cognitive Epidemiology, Medical Genetics Section, University of Edinburgh
  • , Yvonne DavidsonAffiliated withClinical Gerontology, Hope Hospital, University of Manchester
    • , Ian J. DearyAffiliated withDepartment of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
    • , Linda GibbonsAffiliated withClinical Gerontology, Hope Hospital, University of Manchester
    • , Andrew PicklesAffiliated withAge and Cognitive Performance Research Centre, University of Manchester
    • , William OllierAffiliated withBiostatistics Group, University of Manchester
    • , Neil PendletonAffiliated withClinical Gerontology, Hope Hospital, University of Manchester
    • , Jackie F. PriceAffiliated withDivision of Community Health Sciences, University of Edinburgh
    • , Antony PaytonAffiliated withCentre for Integrated Genomic Medical Research, University of Manchester
    • , Nicholas G. MartinAffiliated withGenetic Epidemiology Unit, PO Royal Brisbane Hospital

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Abstract

Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor (CHRM2). In an attempt to replicate this finding we typed marker rs8191992 (the originally reported CHRM2 SNP) in two population based cohorts—one Scottish aged over 50 years (N = 2,091) and the other English comprising non-demented elderly participants (N = 758)—and a family-based Australian adolescent sample (N = 1,537). An additional 29 SNPs in CHRM2 were typed in the Australian sample and a further seven in the English cohort. No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability.

Keywords

Association analyses CHRM2 Cognitive ability Genetics Intelligence