Behavior Genetics

, Volume 39, Issue 5, pp 513–523

No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples

Authors

    • Genetic Epidemiology UnitPO Royal Brisbane Hospital
  • Michelle Luciano
    • Genetic Epidemiology UnitPO Royal Brisbane Hospital
    • Department of Psychology, Centre for Cognitive Ageing and Cognitive EpidemiologyUniversity of Edinburgh
  • Michael A. Horan
    • Clinical Gerontology, Hope HospitalUniversity of Manchester
  • Riccardo E. Marioni
    • Division of Community Health SciencesUniversity of Edinburgh
  • Margaret J. Wright
    • Genetic Epidemiology UnitPO Royal Brisbane Hospital
  • Timothy C. Bates
    • Department of Psychology, Centre for Cognitive Ageing and Cognitive EpidemiologyUniversity of Edinburgh
  • Patrick Rabbitt
    • Age and Cognitive Performance Research CentreUniversity of Manchester
  • Sarah E. Harris
    • Department of Psychology, Centre for Cognitive Ageing and Cognitive EpidemiologyUniversity of Edinburgh
    • Centre for Cognitive Ageing and Cognitive Epidemiology, Medical Genetics SectionUniversity of Edinburgh
  • Yvonne Davidson
    • Clinical Gerontology, Hope HospitalUniversity of Manchester
  • Ian J. Deary
    • Department of Psychology, Centre for Cognitive Ageing and Cognitive EpidemiologyUniversity of Edinburgh
  • Linda Gibbons
    • Clinical Gerontology, Hope HospitalUniversity of Manchester
  • Andrew Pickles
    • Age and Cognitive Performance Research CentreUniversity of Manchester
  • William Ollier
    • Biostatistics GroupUniversity of Manchester
  • Neil Pendleton
    • Clinical Gerontology, Hope HospitalUniversity of Manchester
  • Jackie F. Price
    • Division of Community Health SciencesUniversity of Edinburgh
  • Antony Payton
    • Centre for Integrated Genomic Medical ResearchUniversity of Manchester
  • Nicholas G. Martin
    • Genetic Epidemiology UnitPO Royal Brisbane Hospital
Original Research

DOI: 10.1007/s10519-009-9274-z

Cite this article as:
Lind, P.A., Luciano, M., Horan, M.A. et al. Behav Genet (2009) 39: 513. doi:10.1007/s10519-009-9274-z

Abstract

Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor (CHRM2). In an attempt to replicate this finding we typed marker rs8191992 (the originally reported CHRM2 SNP) in two population based cohorts—one Scottish aged over 50 years (N = 2,091) and the other English comprising non-demented elderly participants (N = 758)—and a family-based Australian adolescent sample (N = 1,537). An additional 29 SNPs in CHRM2 were typed in the Australian sample and a further seven in the English cohort. No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability.

Keywords

Association analysesCHRM2Cognitive abilityGeneticsIntelligence

Copyright information

© Springer Science+Business Media, LLC 2009