Behavior Genetics

, Volume 39, Issue 2, pp 183–191

Studies on Syntaxin 12 and Alcohol Preference Involving C57BL/6J and DBA/2J Strains of Mice

Authors

  • J. Weng
    • Department of BiologyUniversity of Western Ontario
  • M. N. Symons
    • Department of BiologyUniversity of Western Ontario
    • Department of BiologyUniversity of Western Ontario
ORIGINAL RESEARCH

DOI: 10.1007/s10519-008-9249-5

Cite this article as:
Weng, J., Symons, M.N. & Singh, S.M. Behav Genet (2009) 39: 183. doi:10.1007/s10519-008-9249-5

Abstract

C57BL/6J and DBA/2J inbred mouse strains have been extensively studied for the genetic dissection of alcohol-related phenotypes. We have previously found Syntaxin 12 to be associated with alcohol preference in C57BL/6J and DBA/2J due to its strain-specific and ethanol responsive expression in the male brain. In the current study, we combined genetic and expression analyses to assess the segregation of Syntaxin 12 c.*1370G>A polymorphism with its strain-specific expression and alcohol preference in an F2 population (N = 427) derived from C57BL/6J and DBA/2J strains. Syntaxin 12 c.*1370G>A polymorphism was found to segregate with alcohol preference in the B6D2F2 population and a correlation was identified between Syntaxin 12 expression and alcohol preference in the selected B6D2F2 males (= −0.473, r2 = 0.22). We followed up our analysis in the BXD RI lines using resources from WebQTL and the Mouse Phenome Database. Our study detected significant associations of Syntaxin 12 molecular variants with its level of expression and alcohol preference in B6D2F2 males. Overall, our findings support a role for Syntaxin 12 as a potential contributor to alcohol preference in mice.

Keywords

Syntaxin 12Alcohol preferenceC57BL/6JDBA/2JCandidate gene

Supplementary material

10519_2008_9249_MOESM1_ESM.doc (11 kb)
(DOC 10 kb)

Copyright information

© Springer Science+Business Media, LLC 2008