Behavior Genetics

, Volume 39, Issue 2, pp 176–182

Evidence for Epigenetic Interactions for Loci on Mouse Chromosome 1 Regulating Open Field Activity

Authors

  • J. G. de Mooij-van Malsen
    • Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and PharmacologyUniversity Medical Centre Utrecht
  • H. A. van Lith
    • Department of Animal, Science and Society, Division of Laboratory Animal Science, Faculty of Veterinary Medicine and Rudolf Magnus Institute of NeuroscienceUtrecht University
  • H. Oppelaar
    • Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and PharmacologyUniversity Medical Centre Utrecht
  • B. Olivier
    • Rudolf Magnus Institute of Neuroscience and Utrecht Institute for Pharmaceutical Sciences, Department of Psychopharmacology, Faculty of ScienceUtrecht University
    • Department of PsychiatryYale University School of Medicine
    • Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and PharmacologyUniversity Medical Centre Utrecht
Original Research

DOI: 10.1007/s10519-008-9243-y

Cite this article as:
de Mooij-van Malsen, J.G., van Lith, H.A., Oppelaar, H. et al. Behav Genet (2009) 39: 176. doi:10.1007/s10519-008-9243-y

Abstract

The expression of motor activity levels in response to novel situations is under complex genetic and environmental control. Several genetic loci have been implicated in the regulation of this behavioral phenotype, but their relationship to epigenetic and epistatic interactions is relatively unknown. Here, we report on a quantitative trait locus (QTL) on mouse chromosome 1 for novelty-induced motor activity in the open field, using chromosome substitution strains derived from a high active host strain (C57BL/6J) and a low active donor strain (A/J). The QTL for open field (horizontal distance moved) peaked at the location of Kcnj9, however, QTL detection was initially masked by an interplay of both grandparent genetic origin and genetic co-factors influencing behavior on chromosome 1. Our findings indicate that epigenetic interactions can play an important role in the identification of behavioral QTLs and must be taken into consideration when applying behavioral genetic strategies.

Keywords

Chromosome substitution strainsLocomotor activityEpigenetic effectsQuantitative trait locusMouse behavior

Copyright information

© Springer Science+Business Media, LLC 2008