Behavior Genetics

, Volume 37, Issue 2, pp 294–301

Family Based Association Analyses between the Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Neuroticism, Anxiety and Depression

  • Christel M. Middeldorp
  • Eco J. C. de Geus
  • A. Leo Beem
  • Nico Lakenberg
  • Jouke-Jan Hottenga
  • P. Eline Slagboom
  • Dorret I. Boomsma
Original Paper

DOI: 10.1007/s10519-006-9139-7

Cite this article as:
Middeldorp, C.M., de Geus, E.J.C., Beem, A.L. et al. Behav Genet (2007) 37: 294. doi:10.1007/s10519-006-9139-7

Abstract

We studied the association between the short/long promotor-based length polymorphism of the serotonin transporter gene (5-HTTLPR) and neuroticism, anxiety and depression. Subjects included twins, their siblings and parents from the Netherlands Twin Register (559 parents and 1,245 offspring). Subjects had participated between one and five times in a survey study measuring neuroticism, anxiety and depression. Offspring of these families were also approached to participate in a psychiatric interview diagnosing DSM-IV major depression. Within-family and total association between 5-HTTLPR and these traits were tested. Only three of the 36 tests showed a significant effect of 5-HTTLPR (P < 0.05). These effects were in opposite directions, i.e. both negative and positive regression coefficients were found for the s allele. No additive effect of the s allele was found for DSM-IV depression. Our results strongly suggest that there is no straightforward association between 5-HTTLPR and neuroticism, anxiety and depression.

Keywords

5-HTTLPRNeuroticismAnxietyDepressionFamily based association analyses

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Christel M. Middeldorp
    • 1
    • 2
  • Eco J. C. de Geus
    • 1
    • 3
  • A. Leo Beem
    • 1
    • 3
  • Nico Lakenberg
    • 4
  • Jouke-Jan Hottenga
    • 1
    • 3
  • P. Eline Slagboom
    • 4
  • Dorret I. Boomsma
    • 1
  1. 1.Department of Biological PsychologyVrije Universiteit AmsterdamAmsterdamThe Netherlands
  2. 2.Department of PsychiatryVrije Universiteit Medical CenterAmsterdamThe Netherlands
  3. 3.Center for Neurogenomics and Cognitive Research (CNCR)AmsterdamThe Netherlands
  4. 4.Molecular EpidemiologyLeiden University Medical CenterLeidenThe Netherlands