Behavior Genetics

, Volume 37, Issue 2, pp 265–272

Association of CHRM2 with IQ: Converging Evidence for a Gene Influencing Intelligence

Authors

    • Department of Psychiatry Washington University in St. Louis
  • Fazil Aliev
    • Department of Psychiatry Washington University in St. Louis
    • Ankara University
  • John Kramer
    • University of Iowa
  • Jen C. Wang
    • Department of Psychiatry Washington University in St. Louis
  • Anthony Hinrichs
    • Department of Psychiatry Washington University in St. Louis
  • Sarah Bertelsen
    • Department of Psychiatry Washington University in St. Louis
  • Sam Kuperman
    • University of Iowa
  • Marc Schuckit
    • University of California at San Diego
  • John Nurnberger Jr
    • Indiana University
  • Howard J. Edenberg
    • Indiana University
  • Bernice Porjesz
    • SUNY Health Science Center at Brooklyn
  • Henri Begleiter
    • SUNY Health Science Center at Brooklyn
  • Victor Hesselbrock
    • University of Connecticut School of Medicine
  • Alison Goate
    • Department of Psychiatry Washington University in St. Louis
  • Laura Bierut
    • Department of Psychiatry Washington University in St. Louis
Original Paper

DOI: 10.1007/s10519-006-9131-2

Cite this article as:
Dick, D.M., Aliev, F., Kramer, J. et al. Behav Genet (2007) 37: 265. doi:10.1007/s10519-006-9131-2

Abstract

The cholinergic neurotransmitter system is thought to be involved in many aspects of memory, attention, and higher cognition. In the Collaborative Study on the Genetics of Alcoholism (COGA) sample, we have previously reported linkage and association to the cholinergic muscarinic 2 receptor gene (CHRM2) on chromosome 7 with evoked EEG oscillations (Jones et al. 2004), providing evidence that this gene may be involved in human brain dynamics and cognition. In addition, a small number of genetic markers were genotyped in CHRM2 in the Minnesota Twin and Family Study (Comings et al. 2003) and a Dutch family study (Gosso et al. 2006, in press) and both research groups found evidence that this gene may be involved in intelligence. In the COGA sample, we have extensively genotyped SNPs within and flanking the CHRM2 gene. We find evidence of association with multiple SNPs across CHRM2 and Performance IQ, as measured by the Wechsler Adult Intelligence Scale-Revised (WAIS-R). These results remain significant after taking into account alcohol dependence and depression diagnoses in the sample.

Keywords

IntelligenceIQCHRM2Cognitive abilityGeneticsAssociation analyses

Copyright information

© Springer Science+Business Media, LLC 2006