Behavior Genetics

, Volume 36, Issue 5, pp 640–650

Association of GABRA2 with Drug Dependence in the Collaborative Study of the Genetics of Alcoholism Sample

  • Arpana Agrawal
  • Howard J. Edenberg
  • Tatiana Foroud
  • Laura J. Bierut
  • Gerald Dunne
  • Anthony L. Hinrichs
  • John I. Nurnberger
  • Raymond Crowe
  • Samuel Kuperman
  • Marc A. Schuckit
  • Henri Begleiter
  • Bernice Porjesz
  • Danielle M. Dick
Article

DOI: 10.1007/s10519-006-9069-4

Cite this article as:
Agrawal, A., Edenberg, H., Foroud, T. et al. Behav Genet (2006) 36: 640. doi:10.1007/s10519-006-9069-4

Abstract

Results from twin studies suggest that overlapping genetic factors influence alcohol dependence and illicit drug dependence. Using data from the Collaborative Study on the Genetics of Alcoholism (COGA), we examined the association between 69 SNPs in the GABAA receptor gene cluster on chromosome 4 and marijuana and illicit drug dependence, individually, and as co-occurring phenotypes with alcohol dependence. Results suggested association between marijuana dependence and illicit drug dependence with SNPs in the GABRA2 gene. Interestingly, the evidence for association previously observed with alcohol dependence came only from individuals with comorbid illicit drug dependence. There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence.

Keywords

Alcoholismassociation analysesCOGAdrug dependenceGABRA2PDT

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Arpana Agrawal
    • 1
  • Howard J. Edenberg
    • 2
  • Tatiana Foroud
    • 2
  • Laura J. Bierut
    • 1
  • Gerald Dunne
    • 1
  • Anthony L. Hinrichs
    • 1
  • John I. Nurnberger
    • 2
  • Raymond Crowe
    • 3
  • Samuel Kuperman
    • 3
  • Marc A. Schuckit
    • 4
  • Henri Begleiter
    • 5
  • Bernice Porjesz
    • 5
  • Danielle M. Dick
    • 1
    • 6
  1. 1.Department of PsychiatryWashington University in St. LouisSt. LouisUSA
  2. 2.Indiana University School of MedicineIndianapolisUSA
  3. 3.University of IowaIowa CityUSA
  4. 4.University of California–San DiegoSan DiegoUSA
  5. 5.State University of New YorkNew YorkUSA
  6. 6.Department of PsychiatryWashington University in St. LouisSt. LouisUSA