Behavior Genetics

, Volume 36, Issue 1, pp 100–111

Genome-wide Linkage Scan to Identify Loci for Age at First Cigarette in Dutch Sibling Pairs


    • Department of Biological PsychologyVrije Universiteit
    • Department of Biological PsychologyVrije Universiteit
  • Danielle Posthuma
    • Department of Biological PsychologyVrije Universiteit
  • Michael C. Neale
    • Departments of Psychiatry and Human Genetics, Virginia Institute for Psychiatry and Behavioral GeneticsMedical College of Virginia, Virginia Commonwealth University
  • P. Eline Slagboom
    • Section Molecular Epidemiology, Sylvius LaboratoryLeiden University Medical Centre
  • Dorret I. Boomsma
    • Department of Biological PsychologyVrije Universiteit

DOI: 10.1007/s10519-005-9012-0

Cite this article as:
Vink, J., Posthuma, D., Neale, M. et al. Behav Genet (2006) 36: 100. doi:10.1007/s10519-005-9012-0

The heritability of age at first cigarette was estimated in 5883 Dutch twins and siblings registered with the Netherlands Twin Register. Heritability was 60% for males and 39% for females. Shared environmental influences were found in females only (30%). Linkage analyses were performed on data of 422 DZ twins and siblings from 175 families, forming 368 sibling pairs. Genomic regions that may harbor susceptibility loci for age at first cigarette with LOD score greater than 2 were detected on chromosomes 5, 14 and 22. A simultaneous analysis of these three genomic regions showed that most of the variance was explained by the linkage effect on chromosome 5 (205 cM). This peak encloses the D1A dopamine receptor gene which is a functional candidate gene for smoking behavior.


Age at first cigarettedopaminelinkageQTLsex differences

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© Springer 2005