Behavior Genetics

, Volume 36, Issue 1, pp 77–86

Linkage Analyses of IQ in the Collaborative Study on the Genetics of Alcoholism (COGA) Sample

  • Danielle M. Dick
  • Fazil Aliev
  • Laura Bierut
  • Alison Goate
  • John Rice
  • Anthony Hinrichs
  • Sarah Bertelsen
  • Jen C. Wang
  • Gerald Dunn
  • Sam Kuperman
  • Marc Schuckit
  • John NurnbergerJr.
  • Bernice Porjesz
  • Henri Beglieter
  • John Kramer
  • Victor Hesselbrock
Article

DOI: 10.1007/s10519-005-9009-8

Cite this article as:
Dick, D.M., Aliev, F., Bierut, L. et al. Behav Genet (2006) 36: 77. doi:10.1007/s10519-005-9009-8

Intelligence, as measured by standardized psychological tests, has been shown to be highly heritable, though identifying specific genes influencing general intelligence has proven difficult. We conducted genome-wide linkage analyses to identify chromosomal regions containing genes influencing intelligence, as measured by WAIS full-scale IQ (FSIQ), performance IQ (PIQ) and verbal IQ (VIQ). Non-parametric multipoint linkage analyses were conducted with Merlin-regress software, using a sample of 1111 genotyped and phenotyped individuals from 201 families, ascertained as part of the Collaborative Study on the Genetics of Alcoholism (COGA). The strongest evidence of linkage was obtained for FSIQ on chromosome 6 (LOD=3.28, 12 cM) near the marker D6S1006. This region was also implicated with suggestive linkage in a recently published genome screen of IQ in Australian and Dutch twin pairs, and it has been implicated in linkage studies of developmental dyslexia. Our findings provide further support that chromosome 6p contains gene(s) affecting intelligence.

Keywords

Cognitive abilitygeneticsintelligenceIQlinkage analyses

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Danielle M. Dick
    • 1
    • 8
  • Fazil Aliev
    • 1
    • 2
  • Laura Bierut
    • 1
  • Alison Goate
    • 1
  • John Rice
    • 1
  • Anthony Hinrichs
    • 1
  • Sarah Bertelsen
    • 1
  • Jen C. Wang
    • 1
  • Gerald Dunn
    • 1
  • Sam Kuperman
    • 3
  • Marc Schuckit
    • 4
  • John NurnbergerJr.
    • 5
  • Bernice Porjesz
    • 6
  • Henri Beglieter
    • 6
  • John Kramer
    • 3
  • Victor Hesselbrock
    • 7
  1. 1.Department of PsychiatryWashington University in St. LouisSt. LouisUSA
  2. 2.Ankara UniversityAnkaraTurkey
  3. 3.University of IowaIowa CityUSA
  4. 4.University of California at San DiegoSan DiegoUSA
  5. 5.Indiana UniversityIndianapolisUSA
  6. 6.SUNY Health Science Center at BrooklynBrooklynUSA
  7. 7.University of Connecticut School of MedicineFarmingtonUSA
  8. 8.Department of PsychiatryWashington University in St. LouisSt. LouisUSA