Behavior Genetics

, Volume 36, Issue 1, pp 45–55

Genome-wide Scan of IQ Finds Significant Linkage to a Quantitative Trait Locus on 2q

  • M. Luciano
  • M. J. Wright
  • D. L. Duffy
  • M. A. Wainwright
  • G. Zhu
  • D. M. Evans
  • G. M. Geffen
  • G. W. Montgomery
  • N. G. Martin
Article

DOI: 10.1007/s10519-005-9003-1

Cite this article as:
Luciano, M., Wright, M., Duffy, D. et al. Behav Genet (2006) 36: 45. doi:10.1007/s10519-005-9003-1

A genome-wide linkage scan of 795 microsatellite markers (761 autosomal, 34 X chromosome) was performed on Multidimensional Aptitude Battery subtests and verbal, performance and full scale scores, the WAIS-R Digit Symbol subtest, and two word-recognition tests (Schonell Graded Word Reading Test, Cambridge Contextual Reading Test) highly predictive of IQ. The sample included 361 families comprising 2–5 siblings who ranged in age from 15.7 to 22.2 years; genotype, but not phenotype, data were available for 81% of parents. A variance components analysis which controlled for age and sex effects showed significant linkage for the Cambridge reading test and performance IQ to the same region on chromosome 2, with respective LOD scores of 4.15 and 3.68. Suggestive linkage (LOD score>2.2) for various measures was further supported on chromosomes 6, 7, 11, 14, 21 and 22. Where location of linkage peaks converged for IQ subtests within the same scale, the overall scale score provided increased evidence for linkage to that region over any individual subtest. Association studies of candidate genes, particularly those involved in neural transmission and development, will be directed to genes located under the linkage peaks identified in this study.

Keywords

Cognitive abilities genome-wide linkage IQ reading ability twins 

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • M. Luciano
    • 1
  • M. J. Wright
    • 1
  • D. L. Duffy
    • 1
  • M. A. Wainwright
    • 1
  • G. Zhu
    • 1
  • D. M. Evans
    • 1
  • G. M. Geffen
    • 1
  • G. W. Montgomery
    • 1
  • N. G. Martin
    • 1
  1. 1.Queensland Institute of Medical ResearchHerston, BrisbaneAustralia
  2. 2.Queensland Institute of Medical ResearchHerston, BrisbaneAustralia

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