Behavior Genetics

, Volume 35, Issue 4, pp 397–406

Heritability of Smoking Initiation and Nicotine Dependence

  • Jacqueline M. Vink
  • Gonneke Willemsen
  • Dorret I. Boomsma
Article

DOI: 10.1007/s10519-004-1327-8

Cite this article as:
Vink, J.M., Willemsen, G. & Boomsma, D.I. Behav Genet (2005) 35: 397. doi:10.1007/s10519-004-1327-8

Abstract

In contrast to other aspects of smoking behavior, little attention has been paid to the genetics of nicotine dependence. In this paper, three models (single liability dimension, independent liability dimension and combined model) have been applied to data on smoking initiation and nicotine dependence (n = 1572 Dutch twin pairs, mean age 30.5). A combined model best described the data. This model postulates a smoking initiation dimension and a nicotine dependence dimension, which are not independent. For both males and females, individual differences in smoking initiation were explained by genetic (44%), shared environmental (51%) and unique environmental (5%) influences. The nicotine dependence dimension was influenced only by genetic (75%) and unique environmental (25%) factors. The substantial impact of genetic factors on nicotine dependence emphasizes the need for further research to localize and identify specific genes and pathways involved in nicotine dependence.

Keywords

Fagerström test for nicotine dependence (FTND) genetics nicotine dependence smoking initiation twins two-stage model 

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Jacqueline M. Vink
    • 1
    • 2
  • Gonneke Willemsen
    • 1
  • Dorret I. Boomsma
    • 1
  1. 1.Department of Biological PsychologyVrije UniversiteitAmsterdamThe Netherlands
  2. 2.Department of Biological PsychologyVrije UniversiteitAmsterdamThe Netherlands