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Autoantibodies to Plasminogen and Their Role in Tumor Diseases

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Plasma level of IgG autoantibodies to plasminogen was measured by ELISA in patients with benign prostatic hyperplasia (n=25), prostatic cancer (n=17), lung cancer (n=15), and healthy volunteers (n=44). High levels of IgG to plasminogen were found in 2 (12%) of 17 healthy women, in 1 (3.6%) of 27 specimens in a healthy man, in 17 (68%) of 25 specimens in prostatic cancer, in 10 (59%) of 17 specimens in lung cancer, and in 5 (30%) of 15 specimens in benign prostatic hyperplasia. Comparison of plasma levels of anti-plasminogen IgG by affinity chromatography showed 3-fold higher levels in patients with prostatic cancer vs. healthy men.

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Authors and Affiliations

  1. Research Institute of Physicochemical Medicine, Federal Biomedical Agency of Russia, Moscow, Russia

    E. I. Goufman

  2. Angiogen Company, Moscow, Russia

    V. N. Yakovlev

  3. Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia

    N. B. Tikhonova

  4. Chemical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia

    R. B. Aisina & L. I. Mukhametova

  5. V. N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia

    K. N. Yarygin

  6. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia

    K. B. Gershkovich & D. A. Gulin

Authors
  1. E. I. Goufman
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  2. V. N. Yakovlev
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  3. N. B. Tikhonova
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  4. R. B. Aisina
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  5. K. N. Yarygin
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  6. L. I. Mukhametova
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  7. K. B. Gershkovich
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  8. D. A. Gulin
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Corresponding author

Correspondence to E. I. Goufman.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 10, pp. 495-499, October, 2014

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Goufman, E.I., Yakovlev, V.N., Tikhonova, N.B. et al. Autoantibodies to Plasminogen and Their Role in Tumor Diseases. Bull Exp Biol Med 158, 493–496 (2015). https://doi.org/10.1007/s10517-015-2792-1

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  • DOI: https://doi.org/10.1007/s10517-015-2792-1

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