Bulletin of Experimental Biology and Medicine

, Volume 157, Issue 1, pp 103–107

Expression of Insulin-Like Growth Factors in the Placenta in Preeclampsia

  • E. A. Dubova
  • K. A. Pavlov
  • V. M. Lyapin
  • G. V. Kulikova
  • A. I. Shchyogolev
  • G. T. Sukhikh
Morphology and Pathomorphology

DOI: 10.1007/s10517-014-2502-4

Cite this article as:
Dubova, E.A., Pavlov, K.A., Lyapin, V.M. et al. Bull Exp Biol Med (2014) 157: 103. doi:10.1007/s10517-014-2502-4

Comparative morphological study of the placentas in women with preeclampsia and smallfor-date fetuses was carried out. Expression of insulin-like growth factor-1 (IGF-1), insulinlike growth factor-2 (IGF-2), and insulin-like growth factor binding protein-3 (IGFBP-3) was detected by immunohistochemical methods. Low expression of IGF-1 and high expression of IGF-2 and IGFBP-3 in the placental tissue depending on preeclampsia severity were detected. The most pronounced changes were found in preeclampsia associated with small-for-date fetuses.

Key Words

preeclampsiaplacentainsulin-like growth factor (IGF)insulin-like growth factor binding protein-3 (IGFBP-3)

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • E. A. Dubova
    • 1
  • K. A. Pavlov
    • 1
  • V. M. Lyapin
    • 1
  • G. V. Kulikova
    • 1
  • A. I. Shchyogolev
    • 1
  • G. T. Sukhikh
    • 1
  1. 1.V. I. Kulakov Research Center of Obstetrics, Gynecology, and PerinatologyMinistry of Health of the Russian FederationMoscowRussia