, Volume 157, Issue 1, pp 103-107
Date: 11 Jun 2014

Expression of Insulin-Like Growth Factors in the Placenta in Preeclampsia

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Comparative morphological study of the placentas in women with preeclampsia and smallfor-date fetuses was carried out. Expression of insulin-like growth factor-1 (IGF-1), insulinlike growth factor-2 (IGF-2), and insulin-like growth factor binding protein-3 (IGFBP-3) was detected by immunohistochemical methods. Low expression of IGF-1 and high expression of IGF-2 and IGFBP-3 in the placental tissue depending on preeclampsia severity were detected. The most pronounced changes were found in preeclampsia associated with small-for-date fetuses.

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 1, pp. 116-120, January, 2014