Article

Bulletin of Experimental Biology and Medicine

, Volume 155, Issue 3, pp 327-329

Neuroprotective Effects of Individual or Combined Exposure to Hypoxia and Hypercapnia in the Experiment

  • P. P. TregubAffiliated withAltai State Medical University, Ministry of Health and Social Development of the Russian Federation Email author 
  • , V. P. KulikovAffiliated withAltai State Medical University, Ministry of Health and Social Development of the Russian Federation
  • , A. G. BespalovAffiliated withAltai State Medical University, Ministry of Health and Social Development of the Russian Federation
  • , A. Ju. VvedenskyAffiliated withAltai State Medical University, Ministry of Health and Social Development of the Russian Federation
  • , I. S. OsipovAffiliated withAltai State Medical University, Ministry of Health and Social Development of the Russian Federation

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

We studied the effects of hypoxic, hypercapnic, and hypercapnic-hypoxic exposures on brain tolerance to ischemia. All respiratory training modes had a neuroprotective effect, but the most pronounced effect was observed after exposure to hypercapnic hypoxia. Experimental stroke in rats preliminary exposed to hypercapnic hypoxia was associated with minimal neurological defi cit and motor coordination disturbances in comparison with training modes.

Key Words

hypoxia hypercapnia adaptation stroke brain