Bulletin of Experimental Biology and Medicine

, Volume 155, Issue 3, pp 327–329

Neuroprotective Effects of Individual or Combined Exposure to Hypoxia and Hypercapnia in the Experiment

  • P. P. Tregub
  • V. P. Kulikov
  • A. G. Bespalov
  • A. Ju. Vvedensky
  • I. S. Osipov
Article

DOI: 10.1007/s10517-013-2145-x

Cite this article as:
Tregub, P.P., Kulikov, V.P., Bespalov, A.G. et al. Bull Exp Biol Med (2013) 155: 327. doi:10.1007/s10517-013-2145-x

We studied the effects of hypoxic, hypercapnic, and hypercapnic-hypoxic exposures on brain tolerance to ischemia. All respiratory training modes had a neuroprotective effect, but the most pronounced effect was observed after exposure to hypercapnic hypoxia. Experimental stroke in rats preliminary exposed to hypercapnic hypoxia was associated with minimal neurological defi cit and motor coordination disturbances in comparison with training modes.

Key Words

hypoxiahypercapniaadaptationstrokebrain

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • P. P. Tregub
    • 1
  • V. P. Kulikov
    • 1
  • A. G. Bespalov
    • 1
  • A. Ju. Vvedensky
    • 1
  • I. S. Osipov
    • 1
  1. 1.Altai State Medical University, Ministry of Health and Social Development of the Russian FederationBarnaulRussia