Bulletin of Experimental Biology and Medicine

, Volume 152, Issue 5, pp 595–599

β-Endorphin Effects on Antibody Production, Proliferation, and Secretion of Th1/Th2 Cytokines In Vivo

  • S. V. Gein
  • T. A. Baeva
  • V. O. Nebogatikov
  • S. P. Tendryakova
Immunology and Microbiology

DOI: 10.1007/s10517-012-1584-0

Cite this article as:
Gein, S.V., Baeva, T.A., Nebogatikov, V.O. et al. Bull Exp Biol Med (2012) 152: 595. doi:10.1007/s10517-012-1584-0

Intraperitoneal injection of β-endorphin in doses of 1, 0.01, and 0.0005 μg/kg under conditions of systemic immunization increased the count of antibody-producing cells in the spleen and the titer of anti-erythrocyte antibodies in the plasma of experimental animals. Intraperitoneal β-endorphin stimulated proliferative activity of splenocytes in mice in the presence of both B- and T-cell mitogen, did not change the production of IFN-γ, reduced the level of IL-2, and stimulated the secretion of IL-4, the main Th2-polarizing factor.

Key Words

β-endorphin splenocytes cytokines IL-2 IL-4 IFN-γ 

Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • S. V. Gein
    • 1
    • 2
  • T. A. Baeva
    • 1
  • V. O. Nebogatikov
    • 2
  • S. P. Tendryakova
    • 2
  1. 1.Institute of Ecology and Genetics of Microorganisms, the Ural Division of the Russian Academy of SciencesPermRussia
  2. 2.Perm State UniversityPermRussia

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