Bulletin of Experimental Biology and Medicine

, Volume 152, Issue 4, pp 409–412

Effect of Imipramine and Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in the Brain of Rats with Experimental Anxious-Depressive Syndrome

Authors

    • Laboratory for General Pathology of Nervous System, Institute of General Pathology and PathophysiologyRussian Academy of Medical Sciences
  • N. A. Krupina
    • Laboratory for General Pathology of Nervous System, Institute of General Pathology and PathophysiologyRussian Academy of Medical Sciences
  • E. Yu. Kushnareva
    • Laboratory for General Pathology of Nervous System, Institute of General Pathology and PathophysiologyRussian Academy of Medical Sciences
  • N. N. Zolotov
    • Laboratory of Psychopharmacology, V. V. Zakusov Institute of PharmacologyRussian Academy of Medical Sciences
  • G. N. Kryzhanovskii
    • Laboratory for General Pathology of Nervous System, Institute of General Pathology and PathophysiologyRussian Academy of Medical Sciences
General Pathology and Pathophysiology

DOI: 10.1007/s10517-012-1540-z

Cite this article as:
Khlebnikova, N.N., Krupina, N.A., Kushnareva, E.Y. et al. Bull Exp Biol Med (2012) 152: 409. doi:10.1007/s10517-012-1540-z

Activities of prolyl endopeptidase and dipeptidyl peptidase IV in the frontal cortex, hypothalamus, nucleus accumbens, striatum, and hippocampus were measured in rats with the experimental anxious-depressive syndrome induced by treatment with a dipeptidyl peptidase IV inhibitor during the early postnatal period (days 5-18). Prolyl endopeptidase activity was elevated in the frontal cortex, hypothalamus, and nucleus accumbens. Increased activity of dipeptidyl peptidase IV was observed in the hypothalamus and striatum. Norepinephrine/serotonin reuptake inhibitor, imipramine, and noncompetitive prolyl endopeptidase inhibitor, benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine, were shown to abolish depression-like behavior of animals in the forced swimming test. These compounds had a normalizing effect on activities of prolyl endopeptidase and dipeptidyl peptidase IV in brain structures of rats.

Key Words

dipeptidyl peptidase IVprolyl endopeptidasedepressionratsbrain structures
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© Springer Science+Business Media, Inc. 2012