Bulletin of Experimental Biology and Medicine

, Volume 150, Issue 4, pp 468–470

Changes in Apoptosis and Cell Proliferation in Human Pineal Gland during Aging

Authors

  • V. O. Polyakova
    • Saint-Petersburg Institute of Bioregulation and Gerontology, North-West Division, Russian Academy of Medical Sciences
    • Saint-Petersburg Institute of Bioregulation and Gerontology, North-West Division, Russian Academy of Medical Sciences
  • S. A. Pichugin
    • Saint-Petersburg Institute of Bioregulation and Gerontology, North-West Division, Russian Academy of Medical Sciences
Article

DOI: 10.1007/s10517-011-1170-x

Cite this article as:
Polyakova, V.O., Linkova, N.S. & Pichugin, S.A. Bull Exp Biol Med (2011) 150: 468. doi:10.1007/s10517-011-1170-x

Immunohistochemical analysis of the expression of proapoptotic protein P53 and proliferation protein Ki-67 in human pineal gland showed that in people over 60 years pinealocyte proliferation is virtually absent. Moreover, pinealocyte apoptosis is more pronounced in elderly, whereas in senile and long-living individuals its intensity decreases.

Key Words

pineal glandagingapoptosiscell proliferation

Copyright information

© Springer Science+Business Media, Inc. 2011