Morphofunctional Characteristics of Syncytiotrophoblast and Content of Heat Shock Protein 70 in It during Exacerbation of Herpesvirus Infection in Pregnant Women
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- Lutsenko, M.T., Dorofienko, N.N. & Andrievskaya, I.A. Bull Exp Biol Med (2010) 150: 149. doi:10.1007/s10517-010-1090-1
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Exacerbation of herpesvirus infection during pregnancy is associated with damage to syncytiotrophoblast infl icted by herpesvirus either directly or via TNF-α (due to contact of NK lymphocytes with villus surface). A sharp decrease in the content of heat shock protein with a molecular weight of 70 Da and activation of caspase-3 were noted in placenta homogenate. This leads to disturbances in syncytiotrophoblast cytosol structure and increase in the relative content of apoptotic nuclei.