Article

Bulletin of Experimental Biology and Medicine

, Volume 149, Issue 5, pp 587-590

Blood Levels of Inflammatory and Destructive Biomarkers in Coronary Atherosclerosis of Different Severity

  • Yu. I. RaginoAffiliated withInstitute of Therapy, Siberian Division of Russian Academy of Medical Sciences Email author 
  • , A. M. ChernjavskiAffiliated withE. N. Meshalkin Research Institute of Circulatory Pathology, Federal Agency for High-Technological Medical Care
  • , Ya. V. PolonskajaAffiliated withInstitute of Therapy, Siberian Division of Russian Academy of Medical Sciences
  • , S. Yu. TchimbalAffiliated withE. N. Meshalkin Research Institute of Circulatory Pathology, Federal Agency for High-Technological Medical Care
  • , D. A. RedjkinAffiliated withE. N. Meshalkin Research Institute of Circulatory Pathology, Federal Agency for High-Technological Medical Care
  • , E. V. SemaevaAffiliated withE. N. Meshalkin Research Institute of Circulatory Pathology, Federal Agency for High-Technological Medical Care
  • , E. V. KashtanovaAffiliated withInstitute of Therapy, Siberian Division of Russian Academy of Medical Sciences
  • , M. I VoevodaAffiliated withInstitute of Therapy, Siberian Division of Russian Academy of Medical Sciences

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In male patients with coronary atherosclerosis without acute coronary syndrome, the levels of inflammatory-destructive biomarkers of atherosclerotic plaque instability depended on the severity and dissemination of coronary atherosclerosis. The highest levels of C-reactive protein and matrix metalloproteinase 3 were found in men with atherosclerotic involvement of all three main coronary arteries, primarily their middle and distal segments, and in men with predominance of low-grade stenoses (<50%) of coronary arteries in areas of atherosclerotic plaques.

Key Words

coronary atherosclerosis biomarkers of atherosclerotic plaque instability highly sensitive C-reactive protein metalloproteinases