Bulletin of Experimental Biology and Medicine

, Volume 149, Issue 5, pp 587–590

Blood Levels of Inflammatory and Destructive Biomarkers in Coronary Atherosclerosis of Different Severity

Authors

    • Institute of TherapySiberian Division of Russian Academy of Medical Sciences
  • A. M. Chernjavski
    • E. N. Meshalkin Research Institute of Circulatory PathologyFederal Agency for High-Technological Medical Care
  • Ya. V. Polonskaja
    • Institute of TherapySiberian Division of Russian Academy of Medical Sciences
  • S. Yu. Tchimbal
    • E. N. Meshalkin Research Institute of Circulatory PathologyFederal Agency for High-Technological Medical Care
  • D. A. Redjkin
    • E. N. Meshalkin Research Institute of Circulatory PathologyFederal Agency for High-Technological Medical Care
  • E. V. Semaeva
    • E. N. Meshalkin Research Institute of Circulatory PathologyFederal Agency for High-Technological Medical Care
  • E. V. Kashtanova
    • Institute of TherapySiberian Division of Russian Academy of Medical Sciences
  • M. I Voevoda
    • Institute of TherapySiberian Division of Russian Academy of Medical Sciences
Article

DOI: 10.1007/s10517-010-0999-8

Cite this article as:
Ragino, Y.I., Chernjavski, A.M., Polonskaja, Y.V. et al. Bull Exp Biol Med (2010) 149: 587. doi:10.1007/s10517-010-0999-8

In male patients with coronary atherosclerosis without acute coronary syndrome, the levels of inflammatory-destructive biomarkers of atherosclerotic plaque instability depended on the severity and dissemination of coronary atherosclerosis. The highest levels of C-reactive protein and matrix metalloproteinase 3 were found in men with atherosclerotic involvement of all three main coronary arteries, primarily their middle and distal segments, and in men with predominance of low-grade stenoses (<50%) of coronary arteries in areas of atherosclerotic plaques.

Key Words

coronary atherosclerosisbiomarkers of atherosclerotic plaque instabilityhighly sensitive C-reactive proteinmetalloproteinases

Copyright information

© Springer Science+Business Media, Inc. 2010