Experimental NO deficiency induced by L-NAME injection led to the development of arterial hypertension, endothelial dysfunction, and cardiomyocyte hypertrophy and reduced blood content of nitrates and nitrites. Impaza, NO donors, activators of NO-synthase, antioxidants, and antihypertensive preparations produced endothelium-protective effect of different degree.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, Suppl. 1, pp. 154-157, September, 2009
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Pokrovskii, M.V., Kochkarov, V.I., Pokrovskaya, T.G. et al. Comparative Study of Potential Endothelioprotectors and Impaza in Modeled Nitric Oxide Defi ciency. Bull Exp Biol Med 148, 514–517 (2009). https://doi.org/10.1007/s10517-010-0751-4
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DOI: https://doi.org/10.1007/s10517-010-0751-4