, Volume 147, Issue 6, pp 701-703
Date: 29 Oct 2009

Activation of α-Latrotoxin Receptors in Neuromuscular Synapses Leads to a Prolonged Splash Acetylcholine Release

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The mechanisms of acetylcholine release in presynaptic terminals of motoneurons induced by mutant α-latrotoxin (LTN4C) were analyzed. In contrast to wild-type α-latrotoxin that causes both continuous and splash secretion of acetylcholine and necessarity block neuromuscular transmission, LTN4C causes only splash release lasting over many hours. Thus, activation of α-latrotoxin receptors controls long-lasting enhanced secretion of acetylcholine.

Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 147, No. 6, pp. 639-641, June, 2009