Experimental Genetics

Bulletin of Experimental Biology and Medicine

, 147:462

First online:

Gender Effects on Association of Serotonin Transporter Gene Polymorphism with Symptoms of Central Fatigue

  • N. V. MaluchenkoAffiliated withBiological Faculty, M. V. Lomonosov Moscow State University Email author 
  • , J. V. SchegolkovaAffiliated withBiological Faculty, M. V. Lomonosov Moscow State University
  • , M. A. KulikovaAffiliated withBiological Faculty, M. V. Lomonosov Moscow State University
  • , M. A. TimofeevaAffiliated withBiological Faculty, M. V. Lomonosov Moscow State University
  • , V. A. ShlepcovaAffiliated withBiological Faculty, M. V. Lomonosov Moscow State University
  • , O. V. SysoevaAffiliated withRussian National Institute of Physical Education and Sport
  • , A. G. TonevitskyAffiliated withRussian National Institute of Physical Education and Sport

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In order to test the “serotonin” hypothesis of the genesis of central fatigue, we studied association between genotype and fatigue (3-hour mental workload consisting of information processing and logical task solution) using analysis of variance for different indices (well-being, activity, mood, mental fatigue index). It was concluded that young men with serotonin deficit (LL genotype) and girls with serotonin excess (S genotype) were less tolerant to long-lasting mental workload. Thus, we confirmed that the degree of central fatigue depends on the function of the serotonin system and revealed gender differences in adaptive capacities of carriers of different variants of serotonin transporter.

Key Words

polymorphism serotonin transporter central fatigue gender differences