Bulletin of Experimental Biology and Medicine

, Volume 144, Issue 6, pp 791–794

Acceleration of fibril formation and thermal stabilization of collagen fibrils in the presence of taxifolin (dihydroquercetin)

  • Y. S. Tarahovsky
  • I. I. Selezneva
  • N. A. Vasilieva
  • M. A. Egorochkin
  • Yu. A. Kim
Article

DOI: 10.1007/s10517-007-0433-z

Cite this article as:
Tarahovsky, Y.S., Selezneva, I.I., Vasilieva, N.A. et al. Bull Exp Biol Med (2007) 144: 791. doi:10.1007/s10517-007-0433-z

Abstract

We studied the effect of flavonoid taxifolin (dihydriquercetin) on the structure and thermal stability of collagen I fibrils. Taxifolin accelerated fibril formation with reconstruction of periodical cross-striation characteristic of these fibrils. Differential scanning calorimetry showed elevation of melting temperature of collagen fibrils formed in neutral or weakly alkaline media, but not of individual tropocollagen molecules in acid medium. Taxifolin capacity to stimulate fibril formation and promote stabilization of fibrillar forms of collagen can be used in medicine.

Key Words

collagen taxifolin dihydroquercetin flavonoids polyphenols 

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • Y. S. Tarahovsky
    • 1
  • I. I. Selezneva
    • 1
  • N. A. Vasilieva
    • 2
  • M. A. Egorochkin
    • 2
  • Yu. A. Kim
    • 3
  1. 1.Institute of Theoretical and Experimental BiophysicsRussian Academy of SciencesPushchino
  2. 2.Bioflavon FirmObninsk
  3. 3.Institute of Cell BiophysicsRussian Academy of SciencesPushchino

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