Bulletin of Experimental Biology and Medicine

, Volume 144, Issue 1, pp 151–153

Mechanism of mobilization of mesenchymal stem cell under the effect of granulocyte colony-stimulating factor

  • V. V. Zhdanov
  • L. A. Stavrova
  • A. M. Dygai
  • E. D. Goldberg
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)

DOI: 10.1007/s10517-007-0276-7

Cite this article as:
Zhdanov, V.V., Stavrova, L.A., Dygai, A.M. et al. Bull Exp Biol Med (2007) 144: 151. doi:10.1007/s10517-007-0276-7

Abstract

We studied the role of cell components and extracellular matrix of the microenvironment in the mechanisms of mobilization of mesenchymal bone marrow stem cells under the effect of granulocyte colony-stimulating factor in vitro and in vivo on CBA/CaLac mice. It was found that the mechanisms underlying the dissociation effect of granulocyte colony-stimulating factor do not include its direct effect on the interaction of precursor cells with fibronectin. The major role in this process is played by changes in functional state of stromal precursors and cell component of the microenvironment induced by granulocytic colony-stimulating factor and mediated by regulatory systems of the microorganism.

Key Words

granulocyte colony-stimulating factormobilizationfibronectinmesenchymal stem cells

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • V. V. Zhdanov
    • 1
  • L. A. Stavrova
    • 1
  • A. M. Dygai
    • 1
  • E. D. Goldberg
    • 1
  1. 1.Institute of Pharmacology, Tomsk Research CenterSiberian Division of Russian Academy of Medical SciencesRussia