Bulletin of Experimental Biology and Medicine

, Volume 143, Issue 1, pp 114–121

Capability of human mesenchymal cells isolated from different sources to differentiation into tissues of mesodermal origin


  • Yu. G. Suzdal’tseva
    • Russian State Medical University
  • V. V. Burunova
    • Russian State Medical University
  • I. V. Vakhrushev
    • V. N. Orekhovich Research Institute of Biomedical Chemistry
  • V. N. Yarygin
    • Russian State Medical University
  • K. N. Yarygin
    • V. N. Orekhovich Research Institute of Biomedical Chemistry
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) Cell Technologies in Biology and Medicine

DOI: 10.1007/s10517-007-0030-1

Cite this article as:
Suzdal’tseva, Y.G., Burunova, V.V., Vakhrushev, I.V. et al. Bull Exp Biol Med (2007) 143: 114. doi:10.1007/s10517-007-0030-1


We compared the capacity of cultured human skin fibroblasts, human umbilical cord cells obtained after normal delivery on gestation week 38–40, and mesenchymal bone marrow stem cells to differentiation into adipocytes, osteoblasts, and chondrocytes. Our findings suggest that mesenchymal stem cells are multipotent cells and can differentiate into adipose, cartilaginous, and bone tissue. Umbilical cord fibroblast-like cells can differentiate into adipocytes and chondrocytes, and only few cells in this culture can differentiate into osteoblasts. Skin fibroblasts differentiate only into adipocytes.

Key Words

bone marrow mesenchymal stem cellsumbilical cord fibroblast-like cellsskin fibroblasts

Copyright information

© Springer Science+Business Media, Inc. 2007