Bulletin of Experimental Biology and Medicine

, Volume 142, Issue 1, pp 47–50

Effect of homocysteine and homocysteic acid on glutamate receptors on rat lymphocytes

Authors

  • E. A. Vladychenskaya
    • Institute of NeurologyRussian Academy of Medical Sciences
    • M. V. Lomonosov Moscow State University
  • O. V. Tyulina
    • M. V. Lomonosov Moscow State University
    • Institute of NeurologyRussian Academy of Medical Sciences
    • M. V. Lomonosov Moscow State University
Article

DOI: 10.1007/s10517-006-0288-8

Cite this article as:
Vladychenskaya, E.A., Tyulina, O.V. & Boldyrev, A.A. Bull Exp Biol Med (2006) 142: 47. doi:10.1007/s10517-006-0288-8

Abstract

Homocysteine and homocysteic acid increased the stationary level of reactive oxygen species in rat lymphocytes, homocysteic acid being more potent in this respect. The effect of this compound was realized via ionotropic NMDA receptors and group III metabotropic glutamate receptors. Incubation of lymphocytes with homocysteic acid increased intracellular Ca2+ concentration, activated of protein kinase C, and induced accumulation of reactive oxygen species, which reflected the involvement of homocysteic acid into cell signaling mechanisms.

Key Words

glutamate receptorsreactive oxygen specieslymphocyteshomocysteic acidhomocysteine

Copyright information

© Springer Science+Business Media, Inc. 2006