Article

Bulletin of Experimental Biology and Medicine

, Volume 142, Issue 1, pp 47-50

First online:

Effect of homocysteine and homocysteic acid on glutamate receptors on rat lymphocytes

  • E. A. VladychenskayaAffiliated withInstitute of Neurology, Russian Academy of Medical SciencesM. V. Lomonosov Moscow State University
  • , O. V. TyulinaAffiliated withM. V. Lomonosov Moscow State University
  • , A. A. BoldyrevAffiliated withInstitute of Neurology, Russian Academy of Medical SciencesM. V. Lomonosov Moscow State University Email author 

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Abstract

Homocysteine and homocysteic acid increased the stationary level of reactive oxygen species in rat lymphocytes, homocysteic acid being more potent in this respect. The effect of this compound was realized via ionotropic NMDA receptors and group III metabotropic glutamate receptors. Incubation of lymphocytes with homocysteic acid increased intracellular Ca2+ concentration, activated of protein kinase C, and induced accumulation of reactive oxygen species, which reflected the involvement of homocysteic acid into cell signaling mechanisms.

Key Words

glutamate receptors reactive oxygen species lymphocytes homocysteic acid homocysteine