Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)

Bulletin of Experimental Biology and Medicine

, Volume 141, Issue 4, pp 493-499

First online:

Myogenesis in hemopoietic tissue mesenchymal stem cell culture

  • S. N. GornostaevaAffiliated withInstitute of Stem Cell and Cell Technologies Email author 
  • , A. A. RzhaninovaAffiliated withInstitute of Stem Cell and Cell Technologies
  • , D. V. Gol’dsteinAffiliated withInstitute of Stem Cell and Cell TechnologiesReMeTeks

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The myogenic differentiation capacity of prenatal mesenchymal stem cells from the main sites of hemopoiesis (bone marrow, thymus, liver, and spleen) was studied. Myogenesis was observed in all studied cell cultures except splenic mesenchymal stem cells. Differentiating cells from the thymus, bone marrow, and liver were positively stained for skeletal muscle markers (myogenin and MyoD). Autonomously contracting structures positively stained for cardiotroponin I and slow muscle myosin, were detected in the same cultures. Our experiments revealed differences in differentiation of mesenchymal stem cells from hemopoietic organs depending on the source of cells.

Key Words

mesenchymal stem cells myogenesis; differentiation