Bulletin of Experimental Biology and Medicine

, Volume 141, Issue 2, pp 243–246

Genetic status of p53 in stomach cancer: Somatic mutations and polymorphism of codon 72

  • V. A. Belyavskaya
  • V. K. Vardosanidze
  • O. Yu. Smirnova
  • E. I. Karakin
  • I. V. Savkin
  • P. A. Gervas
  • N. V. Cherdyntseva
  • M. I. Voevoda
Article

DOI: 10.1007/s10517-006-0139-7

Cite this article as:
Belyavskaya, V.A., Vardosanidze, V.K., Smirnova, O.Y. et al. Bull Exp Biol Med (2006) 141: 243. doi:10.1007/s10517-006-0139-7

Abstract

The incidence of somatic mutagenesis of p53 oncosuppressor protein in malignant tumors of the stomach and genetic polymorphism of p53 were studied in patients with stomach cancer on DNA samples isolated from tumor tissues obtained during surgery. The incidence of Pro/Pro genotype increased in the patients, while the percentage of Arg/Pro heterozygotes was markedly lower compared to long-living persons without cancer. The incidence of p53 somatic mutations in exons 5, 7, 8 was 70.8%; multiple mutations were detected in half of the examined patients. The relationship between the intensity of p53 mutagenesis and histological structure of the tumor was detected. The contribution of p53 genetic status to the risk of stomach cancer can be more effectively evaluated on DNA samples isolated from not only tumor cells, but also from normal tissues. The effects of epigenetic factors determining the intensity of somatic mutagenesis of p53 in tumors should be taken into account.

Key Words

stomach cancer p53 gene polymorphism somatic mutations 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • V. A. Belyavskaya
    • 1
  • V. K. Vardosanidze
    • 2
  • O. Yu. Smirnova
    • 1
  • E. I. Karakin
    • 1
  • I. V. Savkin
    • 1
  • P. A. Gervas
    • 3
  • N. V. Cherdyntseva
    • 3
  • M. I. Voevoda
    • 1
    • 2
  1. 1.Vector Institute of Virology and BiotechnologyKoltsovo
  2. 2.Institute of TherapySiberian Division of Russian Academy of Medical SciencesNovosibirsk
  3. 3.Institute of Oncology, Tomsk Research CenterSiberian Division of Russian Academy of Medical SciencesRussia

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