Bulletin of Experimental Biology and Medicine

, Volume 141, Issue 1, pp 124–128

Cardiac contractility after transplantation of autologous mononuclear bone marrow cells in patients with myocardial infarction

Authors

  • V. V. Ryabov
    • Institute of Cardiology, Tomsk Research CenterSiberian Division of Russian Academy of Medical Sciences
  • A. L. Krylov
    • Institute of Cardiology, Tomsk Research CenterSiberian Division of Russian Academy of Medical Sciences
  • Yu. S. Poponina
    • Institute of Cardiology, Tomsk Research CenterSiberian Division of Russian Academy of Medical Sciences
    • Institute of Cardiology, Tomsk Research CenterSiberian Division of Russian Academy of Medical Sciences
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)

DOI: 10.1007/s10517-006-0111-6

Cite this article as:
Ryabov, V.V., Krylov, A.L., Poponina, Y.S. et al. Bull Exp Biol Med (2006) 141: 124. doi:10.1007/s10517-006-0111-6

Abstract

Autologous bone marrow mononuclear cells were transplanted by intracoronary infusion to patients with myocardial infarction after recovery of coronary perfusion. Controls received traditional therapy alone. Echocardiography was carried out before and 3 and 6 months after cell therapy. Cell transplantation did not appreciably improved left-ventricular contractility in comparison with the control group. In none patient cell therapy provoked malignant ventricular arrhythmias. Intracoronary infusion of bone marrow mononuclear cells in patients with myocardial infarction did not improve cardiac contractility and did not aggravate the course of the disease.

Key Words

myocardial infarctiontransplantationbone marrow mononuclear cellscardiac contractility

Copyright information

© Springer Science+Business Media, Inc. 2006