Bulletin of Experimental Biology and Medicine

, Volume 140, Issue 5, pp 640–643

Autologous Mononuclear Bone Marrow Cells during Reparative Regeneratrion after Acute Myocardial Infarction

  • R. S. Karpov
  • S. V. Popov
  • V. A. Markov
  • T. E. Suslova
  • V. V. Ryabov
  • Yu. S. Poponina
  • A. L. Krylov
  • S. V. Sazonova
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)

DOI: 10.1007/s10517-006-0043-1

Cite this article as:
Karpov, R.S., Popov, S.V., Markov, V.A. et al. Bull Exp Biol Med (2005) 140: 640. doi:10.1007/s10517-006-0043-1

Abstract

A randomized controlled study included 44 patients with acute myocardial infarction. It was found that intracoronary injection of bone marrow mononuclear cells is safe, ensures fixation of the injected cells in the myocardium, reduces blood levels of IL-1β and TNF-α, increases the content insulin-like growth factor, and does not provoke malignant arrhythmias.

Key Words

myocardial infarction mononuclear bone marrow cells cell cardiomyoplasty 

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • R. S. Karpov
    • 1
  • S. V. Popov
    • 1
  • V. A. Markov
    • 1
  • T. E. Suslova
    • 1
  • V. V. Ryabov
    • 1
  • Yu. S. Poponina
    • 1
  • A. L. Krylov
    • 1
  • S. V. Sazonova
    • 1
  1. 1.Institute of Cardiology, Tomsk Research Center, Siberian DivisionRussian Academy of Medical SciencesTomskRussia

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