Chemical eye burns were accompanied by free radical oxidation of lipids and dysfunction of the antioxidant protection system. The decrease in antioxidant activity of blood plasma reflected a generalized type of these processes. The concentration of thiobarbituric acid-reactive substances increased in blood plasma from rabbits with eye burns. The severity of disturbances was maximum at the stage of trophic disorders. Combination therapy with antioxidants and standard pharmaceuticals effectively inhibited lipid peroxidation in eye tissue of experimental animals.