Bulletin of Experimental Biology and Medicine

, Volume 140, Issue 2, pp 228–230

Vascular Endothelium Growth Factor in the Sera of Patients with Adrenal Tumors

  • T. A. Britvin
  • I. A. Kazantseva
  • A. P. Kalinin
  • N. E. Kushlinskii
Oncology

DOI: 10.1007/s10517-005-0452-6

Cite this article as:
Britvin, T.A., Kazantseva, I.A., Kalinin, A.P. et al. Bull Exp Biol Med (2005) 140: 228. doi:10.1007/s10517-005-0452-6

Abstract

Serum levels of vascular endothelium growth factor were measured in 43 patients with adrenal tumors and 25 healthy subjects. The mean blood levels of the factor in patients with adrenal tumors significantly surpassed the control. No correlations between the level of vascular endothelium growth factor, patient's age and sex were detected. The levels of this factor were maximum in patients with adrenocortical cancer, but its mean level differed negligibly from that in other morphological variants of tumors. The level of vascular endothelium growth factor tended to increase with increasing the stage of adrenocortical cancer. A direct correlation was revealed between the level of vascular endothelium growth factor and tumor size in adrenocortical cancer and aldosterone-producing adenoma. Presumably, vascular endothelium growth factor is involved into mechanisms of growth, invasion, and metastatic growth of adrenocortical cancer.

Key Words

angiogenesisvascular endothelium growth factoradrenal tumors

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • T. A. Britvin
    • 1
  • I. A. Kazantseva
    • 1
  • A. P. Kalinin
    • 1
  • N. E. Kushlinskii
    • 2
  1. 1.M. F. Vladimirskii Moscow Regional Research and Clinical InstituteMoscowRussia
  2. 2.N. N. Blokhin Russian Oncological Research CenterRussian Academy of Medical SciencesMoscowRussia