Bulletin of Experimental Biology and Medicine

, Volume 139, Issue 1, pp 101–104

Morphological changes in immune and endocrine organs of mice injected with a gonadotropin-releasing hormone analog

  • I. I. Bobyntsev
  • A. A. Dolzhikov
  • L. A. Sever’yanova
Article

DOI: 10.1007/s10517-005-0225-2

Cite this article as:
Bobyntsev, I.I., Dolzhikov, A.A. & Sever’yanova, L.A. Bull Exp Biol Med (2005) 139: 101. doi:10.1007/s10517-005-0225-2

Abstract

Infection of surfagon (gonadotropin-releasing hormone analog) in a dose of 0.1 µg/kg to male CBA mice stimulated lymphocyte migration from splenic B zones, caused moderate thinning of the thymic cortex, thickening of the zona fasciculata of the adrenal cortex with signs of corticocyte activation. After administration of 5 µg/kg surfagon we observed alteration of the splenic T zone, drastic thinning of the thymic cortex, and extension of the zona glomeruloza in the adrenal cortex. These effects were retained after castration, which attests to their steroid-independent nature.

Key Words

gonadotropin releasing hormone analog thymus spleen adrenals castration 

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • I. I. Bobyntsev
    • 1
  • A. A. Dolzhikov
    • 1
  • L. A. Sever’yanova
    • 1
  1. 1.Department of Pathophysiology, Department of HistologyKursk State Medical UniversityKursk

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