, Volume 139, Issue 1, pp 101-104

Morphological changes in immune and endocrine organs of mice injected with a gonadotropin-releasing hormone analog

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Infection of surfagon (gonadotropin-releasing hormone analog) in a dose of 0.1 µg/kg to male CBA mice stimulated lymphocyte migration from splenic B zones, caused moderate thinning of the thymic cortex, thickening of the zona fasciculata of the adrenal cortex with signs of corticocyte activation. After administration of 5 µg/kg surfagon we observed alteration of the splenic T zone, drastic thinning of the thymic cortex, and extension of the zona glomeruloza in the adrenal cortex. These effects were retained after castration, which attests to their steroid-independent nature.

This revised version was published online in July 2005 with the addition of the issue title
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 1, pp. 116–120, January, 2005