Morphological changes in immune and endocrine organs of mice injected with a gonadotropin-releasing hormone analog
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- Bobyntsev, I.I., Dolzhikov, A.A. & Sever’yanova, L.A. Bull Exp Biol Med (2005) 139: 101. doi:10.1007/s10517-005-0225-2
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Infection of surfagon (gonadotropin-releasing hormone analog) in a dose of 0.1 µg/kg to male CBA mice stimulated lymphocyte migration from splenic B zones, caused moderate thinning of the thymic cortex, thickening of the zona fasciculata of the adrenal cortex with signs of corticocyte activation. After administration of 5 µg/kg surfagon we observed alteration of the splenic T zone, drastic thinning of the thymic cortex, and extension of the zona glomeruloza in the adrenal cortex. These effects were retained after castration, which attests to their steroid-independent nature.