Original Paper


, Volume 21, Issue 3, pp 439-454

First online:

Some Thoughts on A. H. Louie’s “More Than Life Itself: A Reflection on Formal Systems and Biology”

  • Claudio GutiérrezAffiliated withDepartamento de Ciencias de la Computación, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile
  • , Sebastián JaramilloAffiliated withDepartamento de Biología, Facultad de Ciencias, Universidad de Chile
  • , Jorge Soto-AndradeAffiliated withDepartamento de Matemáticas, Facultad de Ciencias, Centro de Investigación Avanzada en Educación, Universidad de Chile Email author 

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We review and discuss A. H. Louie’s book “More than Life Itself: A Reflexion on Formal Systems and Biology” from an interdisciplinary viewpoint, involving both biology and mathematics, taking into account new developments and related theories.


Relational biology Systems biology (M,R) systems Robert Rosen Efficient causation Autopoiesis Organizational closure Metabolism Computability Self-reference Ouroborus equation