, Volume 16, Issue 1-2, pp 155-163

A Computational Model of Oncogenesis using the Systemic Approach

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Abstract

A new theoretical model of oncogenesis that incorporates a systemic view of biodynamics was developed and analyzed. According to our model, the emergent behavior at the cell population level is the result of nonlinear interactions between the neoplastic and immune subsystems. Our approach allows subsequent extensions of the model to span multiple levels of biological organization. The model opens the possibility of a flexible connection between the molecular and tissue level descriptions of oncogenesis.