Diabetes and Apoptosis

Apoptosis

, 14:1389

First online:

Beta cell apoptosis in diabetes

  • Helen E. ThomasAffiliated withSt. Vincent’s Institute of Medical ResearchDepartment of Medicine, St. Vincent’s Hospital, The University of Melbourne Email author 
  • , Mark D. McKenzieAffiliated withSt. Vincent’s Institute of Medical ResearchDepartment of Medicine, St. Vincent’s Hospital, The University of Melbourne
  • , Eveline AngstetraAffiliated withSt. Vincent’s Institute of Medical ResearchDepartment of Medicine, St. Vincent’s Hospital, The University of Melbourne
  • , Peter D. CampbellAffiliated withSt. Vincent’s Institute of Medical ResearchDepartment of Medicine, St. Vincent’s Hospital, The University of Melbourne
  • , Thomas W. KayAffiliated withSt. Vincent’s Institute of Medical ResearchDepartment of Medicine, St. Vincent’s Hospital, The University of Melbourne

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Apoptosis of beta cells is a feature of both type 1 and type 2 diabetes as well as loss of islets after transplantation. In type 1 diabetes, beta cells are destroyed by immunological mechanisms. In type 2 diabetes abnormal levels of metabolic factors contribute to beta cell failure and subsequent apoptosis. Loss of beta cells after islet transplantation is due to many factors including the stress associated with islet isolation, primary graft non-function and allogeneic graft rejection. Irrespective of the exact mediators, highly conserved intracellular pathways of apoptosis are triggered. This review will outline the molecular mediators of beta cell apoptosis and the intracellular pathways activated.

Keywords

Diabetes Pancreatic beta cells Islet transplantation Apoptosis