Mitochondrial carriers and pores: Key regulators of the mitochondrial apoptotic program?
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- Schwarz, M., Andrade-Navarro, M.A. & Gross, A. Apoptosis (2007) 12: 869. doi:10.1007/s10495-007-0748-2
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Mitochondria play a pivotal role in the process of apoptosis. Alterations in mitochondrial structure and function during apoptosis are regulated by proteins of the BCL-2 family, however their exact mechanism of action is largely unknown. Mitochondrial carriers and pores play an essential role in maintaining the normal function of mitochondria, and BCL-2 family members were shown to interact with several mitochondrial carriers/pores and to affect their function. This review focuses on the involvement of several of these mitochondrial carriers/pores in the regulation of the mitochondrial death pathway.