, Volume 12, Issue 5, pp 869–876

Mitochondrial carriers and pores: Key regulators of the mitochondrial apoptotic program?


  • Michal Schwarz
    • Department of Biological RegulationWeizmann Institute of Science
  • Miguel A. Andrade-Navarro
    • Ottawa Health Research Institute
    • Faculty of Medicine, Department of Cellular and Molecular MedicineUniversity of Ottawa
    • Department of Biological RegulationWeizmann Institute of Science

DOI: 10.1007/s10495-007-0748-2

Cite this article as:
Schwarz, M., Andrade-Navarro, M.A. & Gross, A. Apoptosis (2007) 12: 869. doi:10.1007/s10495-007-0748-2


Mitochondria play a pivotal role in the process of apoptosis. Alterations in mitochondrial structure and function during apoptosis are regulated by proteins of the BCL-2 family, however their exact mechanism of action is largely unknown. Mitochondrial carriers and pores play an essential role in maintaining the normal function of mitochondria, and BCL-2 family members were shown to interact with several mitochondrial carriers/pores and to affect their function. This review focuses on the involvement of several of these mitochondrial carriers/pores in the regulation of the mitochondrial death pathway.


ApoptosisMitochondrial carrier proteinsMitochondrial poresBCL-2 family membersBIDMitochondrial carrier homolog 2 (Mtch2)ADP/ATP translocase (ANT)Voltage dependent anion channel (VDAC)
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© Springer Science + Business Media, LLC 2007