Article

Apoptosis

, Volume 12, Issue 5, pp 869-876

Mitochondrial carriers and pores: Key regulators of the mitochondrial apoptotic program?

  • Michal SchwarzAffiliated withDepartment of Biological Regulation, Weizmann Institute of Science
  • , Miguel A. Andrade-NavarroAffiliated withOttawa Health Research InstituteFaculty of Medicine, Department of Cellular and Molecular Medicine, University of Ottawa
  • , Atan GrossAffiliated withDepartment of Biological Regulation, Weizmann Institute of Science Email author 

Abstract

Mitochondria play a pivotal role in the process of apoptosis. Alterations in mitochondrial structure and function during apoptosis are regulated by proteins of the BCL-2 family, however their exact mechanism of action is largely unknown. Mitochondrial carriers and pores play an essential role in maintaining the normal function of mitochondria, and BCL-2 family members were shown to interact with several mitochondrial carriers/pores and to affect their function. This review focuses on the involvement of several of these mitochondrial carriers/pores in the regulation of the mitochondrial death pathway.

Keywords

Apoptosis Mitochondrial carrier proteins Mitochondrial pores BCL-2 family members BID Mitochondrial carrier homolog 2 (Mtch2) ADP/ATP translocase (ANT) Voltage dependent anion channel (VDAC)