, Volume 10, Issue 1, pp 19–24

Multiple roles of matrix metalloproteinases during apoptosis


DOI: 10.1007/s10495-005-6058-7

Cite this article as:
Mannello, F., Luchetti, F., Falcieri, E. et al. Apoptosis (2005) 10: 19. doi:10.1007/s10495-005-6058-7


Structural, molecular and biochemical approaches have contributed to piecing together the puzzle of how matrix metalloproteinases (MMPs) work and contribute to various disease processes. However, MMPs have many unexpected substrates other than components of the extracellular matrix which profoundly influence cell behaviour, survival and death. With the current understanding of diverse/novel roles of matrix metalloproteinases—particularly their direct or indirect relevance for the early steps during programmed cell death—some seemingly contrasting results seem less surprising. To better target MMPs an appreciation of their many extracellular, intracellular and intranuclear functions, often acting in opposing directions with paradoxical roles in cell death, is carefully required.


anoikis apoptosis extracellular matrix matrix metalloproteinases nucleus 

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • F. Mannello
    • 1
  • F. Luchetti
    • 2
  • E. Falcieri
    • 2
  • S. Papa
    • 2
    • 3
  1. 1.Istituto di Istologia ed Analisi di LaboratorioITOI-CNRBolognaItaly
  2. 2.Istituto di Scienze MorfologicheBolognaItaly
  3. 3.Centro di Citometria e CitomorfologiaUniversità degli Studi “Carlo Bo”UrbinoItaly
  4. 4.Istituto di Istologia ed Analisi di Laboratorio, Via E. Zeppi sncUniversità Studi di Urbino “Carlo Bo”UrbinoItaly

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