Applied Psychophysiology and Biofeedback

, Volume 30, Issue 3, pp 307–317

fMRI Hippocampal Activity During a VirtualRadial Arm Maze

  • Robert S. Astur
  • Sarah A. St. Germain
  • Elizabeth K. Baker
  • Vince Calhoun
  • Godfrey D. Pearlson
  • R. Todd Constable
Article

DOI: 10.1007/s10484-005-6385-z

Cite this article as:
Astur, R.S., St. Germain, S.A., Baker, E.K. et al. Appl Psychophysiol Biofeedback (2005) 30: 307. doi:10.1007/s10484-005-6385-z

Abstract

Numerous studies have shown that the hippocampus is critical for spatial memory. Within nonhuman research, a task often used to assess spatial memory is the radial arm maze. Because of the spatial nature of this task, this maze is often used to assess the function of the hippocampus. Our goal was to extrapolate this task to humans and examine whether healthy undergraduates utilize their hippocampus while performing a virtual reality version of the radial arm maze task. Thirteen undergraduates performed a virtual radial arm maze during functional magnetic resonance imaging. The brain maps of activity reveal bilateral hippocampal BOLD signal changes during the performance of this task. However, paradoxically, this BOLD signal change decreases during the spatial memory component of the task. Additionally, we note frontal cortex activity reflective of working memory circuits. These data reveal that, as predicted by the rodent literature, the hippocampus is involved in performing the virtual radial arm maze in humans. Hence, this virtual reality version may be used to assess the integrity of hippocampus so as to predict risk or severity in a variety of psychiatric disorders.

Keywords

fMRI (functional magnetic resonance imaging) radial arm maze memory hippocampus virtual reality 

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Robert S. Astur
    • 1
    • 2
  • Sarah A. St. Germain
    • 1
  • Elizabeth K. Baker
    • 1
  • Vince Calhoun
    • 1
    • 2
  • Godfrey D. Pearlson
    • 1
    • 2
  • R. Todd Constable
    • 3
    • 4
  1. 1.Olin Neuropsychiatry Research CenterInstitute of LivingHartford
  2. 2.Department of PsychiatryYale School of MedicineNew Haven
  3. 3.Department of Diagnostic RadiologyYale School of MedicineNew Haven
  4. 4.Department of NeurosurgeryYale School of MedicineNew Haven