Antonie van Leeuwenhoek

, Volume 103, Issue 5, pp 947–961

Cyanobacteria: potential candidates for drug discovery

Review Paper

DOI: 10.1007/s10482-013-9898-0

Cite this article as:
Dixit, R.B. & Suseela, M.R. Antonie van Leeuwenhoek (2013) 103: 947. doi:10.1007/s10482-013-9898-0

Abstract

Cyanobacteria are a rich source of vast array of bioactive molecules including toxins with wide pharmaceutical importance. They show varied bioactivities like antitumor, antiviral, antibacterial, antifungal, antimalarial, antimycotics, antiproliferative, cytotoxicity, immunosuppressive agents and multi-drug resistance reversers. A number of techniques are now developed and standardized for the extraction, isolation, detection and purification of cyanobacterial bioactive molecules. Some of the compounds are showing interesting results and have successfully reached to phase II and phase III of clinical trials. These compounds also serve as lead compounds for the development of synthetic analogues with improved bioactivity. Cyanobacterial bioactive molecules hold a bright and promising future in scientific research and great opportunity for drug discovery. This review mainly focuses on anticancerous, antiviral and antibacterial compounds from cyanobacteria; their clinical status; extraction and detection techniques.

Keywords

Bioactive moleculesAnticancerousAntiviralAntimicrobialClinical trialsExtraction methods

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Algology SectionCSIR-National Botanical Research InstituteLucknowIndia