Original Paper

AIDS and Behavior

, Volume 17, Issue 6, pp 2075-2083

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Peer-Education Intervention to Reduce Injection Risk Behaviors Benefits High-Risk Young Injection Drug Users: A Latent Transition Analysis of the CIDUS 3/DUIT Study

  • Mary E. Mackesy-AmitiAffiliated withDivision of Epidemiology and Biostatistics, School of Public Health, University of Illinois at ChicagoCommunity Outreach Intervention Projects, School of Public Health, MC 923, University of Illinois at Chicago Email author 
  • , Lorna FinneganAffiliated withDepartment of Health Systems Science, College of Nursing, University of Illinois at Chicago
  • , Lawrence J. OuelletAffiliated withDivision of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago
  • , Elizabeth T. GolubAffiliated withBloomberg School of Public Health, Johns Hopkins University
  • , Holly HaganAffiliated withCenter for Drug Use and HIV Research, National Development and Research Institutes
  • , Sharon M. HudsonAffiliated withHealth Research Association
  • , Mary H. LatkaAffiliated withThe Aurum Institute
  • , Richard S. GarfeinAffiliated withDivision of Global Public Health, School of Medicine, University of California


We analyzed data from a large randomized HIV/HCV prevention intervention trial with young injection drug users (IDUs) conducted in five U.S. cities. The trial compared a peer education intervention (PEI) with a time-matched, attention control group. Applying categorical latent variable analysis (mixture modeling) to baseline injection risk behavior data, we identified four distinct classes of injection-related HIV/HCV risk: low risk, non-syringe equipment-sharing, moderate-risk syringe-sharing, and high-risk syringe-sharing. The trial participation rate did not vary across classes. We conducted a latent transition analysis using trial baseline and 6-month follow-up data, to test the effect of the intervention on transitions to the low-risk class at follow-up. Adjusting for gender, age, and race/ethnicity, a significant intervention effect was found only for the high-risk class. Young IDU who exhibited high-risk behavior at baseline were 90 % more likely to be in the low-risk class at follow-up after the PEI intervention, compared to the control group.


Injection drug use Intervention HIV HCV Latent class analysis