Barriers to Medication Adherence in Behaviorally and Perinatally Infected Youth Living with HIV
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The study explored barriers to antiretroviral medication adherence in perinatally and behaviorally HIV infected adolescents and young adults in a cross-sectional, multisite sample. The study included a subset of a convenience sample from a cross-sectional analysis. Participants were youth with HIV ages 12–24 who were prescribed HIV medication and reported missing medication in the past 7 days (n = 484, 28.4 % of protocol sample). The top barriers were similar for perinatally and behaviorally infected youth, but perinatally infected youth reported significantly more barriers. Forgetting, not feeling like taking medication and not wanting to be reminded of HIV infection were the most common barriers reported. Number of barriers was significantly correlated with percent of doses missed, viral load, and psychological distress for perinatally infected youth and with doses missed, psychological distress, and substance use for behaviorally infected youth. Interventions to improve adherence to HIV medications should not only address forgetfulness and choosing not to take medications, but also consider route of infection.
- Joint United Nations Programme on HIV/AIDS. Report on the global AIDS epidemic. Mexico City, August: International AIDS Conference; 2008.
- Arnett JJ. Emerging adulthood: the winding road from the late teens through the twenties. New York: Oxford University Press; 2004.
- Simoni JM, Montgomery A, Martin E, New M, Demas PA, Rana S. Adherence to Antiretroviral Therapy for pediatric HIV infection: a qualitative systematic review with recommendations for research and clinical management. Pediatrics. 2007;119:e1371–83. CrossRef
- Hazra R, Siberry GK, Mofenson LM. Growing up with HIV: children, adolescents, and young adults with perinatally acquired HIV infection. Annu Rev Med. 2010;61:169–85. CrossRef
- Koenig LJ, Nesheim S, Abramowitz S. Adolescents with perinatally acquired HIV: emerging behavioral and health needs for long-term survivors. Curr Opin Obstet Gynecol. 2011;23(5):321–7. CrossRef
- Foster C, Fidler S. Adolescents with perinatally acquired HIV-1 Infection. Eur Infect Dis. 2011;5(1):10–6.
- Rudy B, Murphy D, Harris R, Muenz L, Ellen J. Prevalence and interactions of patient-related risks for nonadherence to antiretroviral therapy among perinatally infected youth in the United States. AIDS Patient Care STDs. 2010;24(2):97–104. CrossRef
- Bangsberg DR, Perry S, Charlebois ED, et al. Non-adherence to highly active antiretroviral therapy predicts progression to AIDS. AIDS. 2001;15:1181–3. CrossRef
- Murphy DA, Sarr M, Durako SJ, Moscicki AB, Wilson CM, Muenz LR. Barriers to HAART adherence among Human Immunodeficiency Virus-infected adolescents. Arch Pediatr Adolesc Med. 2003;157:249–55. CrossRef
- MacDonell KE, Naar-King S, Murphy DA, Parsons JT, Huszti H. Situational temptation for HIV medication adherence in high-risk youth. AIDS Patient Care STDs. 2011;25(1):47–52. CrossRef
- Derogatis LR, Spencer PM. The brief symptom inventory (BSI): administration, and procedures manual-I. Baltimore, MD: Clinical Psychometric Research.
- Knight JR, Shrier LA, Bravender TJ, Farrell M, Vander Bilt J, Shafer HJ. A new brief screen for adolescent substance abuse. Arch Pediatr Adolesc Med. 1999;53:591–6.
- Shiffman S, Stone AA, Hufford MR. Ecological momentary assessment. Ann Rev Clin Psychol. 2008;4:1–32. CrossRef
- Woods PW, Moran LM, Carey CL, Dawson MS. ludicello JE, Gibson S, Grant I, Atkinson JH, the HIV Neurobehavioral Research Center (HNRC) Group. Prospective memory in HIV infection: Is “remembering to remember” a unique predictor of self-reported medication management? Arch Clin Neuropsychol. 2008;23(3):257–70.
- Gonzalez JS, Penedo FJ, Llabre MM, Duran RE, Antoni MH, Schneiderman N, Horne R. Physical symptoms, beliefs about medications, negative mood, and long-term HIV medication adherence. Ann Behav Med. 2007;34(1):46–55. CrossRef
- Ammassari A, Murri R, Pezzotti P, et al. Self-reported symptoms and medication side effects influence adherence to highly active antiretroviral therapy in persons with HIV-infection. J Acquir Immune Defic Syndr. 2001;28:445–9.
- Roux P, Kouanfack C, Cohen J, Marcellin F, Boyer S, Delaporte E, Carrieri P, Laurent C, Spire B, the Stratall ANRS 12110/ESTHER Study Group. Adherence to antiretroviral treatment in HIV-positive patients in the Cameroon content: Promoting the use of medication reminder methods. J AIDS. 2011;57(6S):S40–S43.
- Tanney MR, Naar-King S, MacDonell K. Depression and stigma in high-risk youth living with HIV: a multi-site study. J Pediatr Health Care (in press).
- Rintamaki LS, Davis TC, Skripkauskas S, Bennett CL, Wolf MS. Social stigma concerns and HIV medication adherence. AIDS Patient Care STDs. 2006;20(5):359–68. CrossRef
- Naar-King S, Kolmodin K, Parsons JT, Murphy DA. the ATN Protocol Team. Psychosocial factors and substance use in high risk youth living with HIV: a multisite study. AIDS Care. 2010;22(4):475–82.
- British HIV Association/Medical Society for the Study of Venereal Diseases (MSSVD). Guidelines on provision of adherence support to individuals receiving antiretroviral therapy. http://www.aidsmap.com/cms1032065. Accessed February 12, 2012; 2002.
- Stone A, Shiffman S. Ecological momentary assessment (EMA) in behavioral medicine. Ann Behav Med. 1994;16(3):199–202.
- Haberer J, Kahane J, Kigozi I, Emenyonu N, Hunt P, Martin J, Bangsberg D. Real-time adherence monitoring for HIV antiretroviral therapy. AIDS Behav. 2010;14:1340–6. CrossRef
- Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. October 14, 2011;1–167. http://aidsinfo.nih.gov/contentfiles/AdultandAdolescentGL.pdf. Accessed February 21, 2012.
- Duncan LG, Moskowitz JT, Neilands TB, Dilworth SE, Hecht FM, Johnson MO. Mindfulness-based stress reduction for HIV treatment side effects: a randomized, wait-list controlled trial. J Pain Symptom Manage. 2012;43(2):161–71. CrossRef
- Barriers to Medication Adherence in Behaviorally and Perinatally Infected Youth Living with HIV
AIDS and Behavior
Volume 17, Issue 1 , pp 86-93
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Antiretroviral medication adherence
- Route of infection
- Barriers to adherence
- Youth living with HIV
- Intervention development
- Industry Sectors
- Author Affiliations
- 1. Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
- 2. Department of Pediatric Psychology, Children’s Hospital of Orange County, Orange, CA, USA
- 3. Division of Adolescent Medicine, University of Southern California and Children’s Hospital of Los Angeles, Los Angeles, CA, USA