Unexamined Challenges to Applying the Treatment as Prevention Model Among Men Who Have Sex with Men in the United States: A Community Public Health Perspective
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Last year’s HIV Prevention Trials Network 052 study documented substantial reductions in HIV transmission to partners by persons living with HIV who had initiated early antiretroviral treatment . The study’s initial findings revealed that just one new HIV infection traceable to a treated partner occurred in the early treatment arm, whereas 27 such new infections occurred in the delayed treatment arm. This difference represents a 96 % reduction in new infections amongst partners of those who took antiretroviral treatment throughout the entire course of the study. Seeking to meet the National HIV/AIDS Strategy goal of reducing new infections 25 % by 2015, the Centers for Disease Control’s new High Impact Prevention approach for the United States now prioritizes expanded HIV testing and antiretroviral treatment . Even before the release of HPTN 052 results, expanded HIV screening and treatment in the U.S. had been modeled to be cost effective, though only moderately successful in re ...
- Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365:493–505. CrossRef
- Mermin J. The science and practice of HIV prevention in the United States. In: 18th conference on retroviruses and opportunistic infections, Boston, 2011, 27 Feb–2 Mar. Paper #19. http://retroconference.org/2011/Abstracts/42633.htm. Accessed 16 Mar 2012.
- Long EF, Brandeau ML, Owens DK. The cost-effectiveness and population outcomes of expanded HIV screening and antiretroviral treatment in the United States. Ann Intern Med. 2010;153(12):778–89.
- Cohen MS, Muessig KE, Smith MK, Powers K, Kashuba AD. Antiviral agents and HIV prevention: controversies, conflicts and consensus. AIDS. 2012 (Epub ahead of print).
- Reynolds SJ, Makumbi F, Nakigozi G, Kagaayi J, Gray RH, Wawer M, Quinn TC, Serwadda D. HIV-1 transmission among HIV-1 discordant couples before and after the introduction of antiretroviral therapy. AIDS. 2011;25(4):473–7. CrossRef
- El-Sadr WM, Coburn BJ, Blower S. Modeling the impact on the HIV epidemic of treating discordant couples with antiretrovirals to prevent transmission. AIDS. 2011;25(18):2295–9. CrossRef
- Fenton K, Mermin J, Centers for Disease Control and Prevention. eHAP Direct. 2011. http://www.cdc.gov/hiv/ehap/resources/direct/05132011/discordant.htm. Accessed 16 Mar 2012.
- Centers for Disease Control and Prevention. High impact HIV prevention: CDC’s approach to reducing HIV infections in the United States. 2011. http://www.cdc.gov/hiv/strategy/dhap/pdf/nhas_booklet.pdf. Accessed 16 Mar 2012.
- Hall HI, Song R, Rhodes P, Prejean J, An Q, Lee LM, et al. Estimation of HIV incidence in the United States. JAMA. 2008;300:520–9. CrossRef
- Centers for Disease Control and Prevention. Trends in HIV/AIDS diagnoses among men who have sex with men: 33 states, 2001–2006. MMWR Morb Mortal Wkly Rep. 2008;57:681–6.
- Millet GA, Flores SA, Peterson JL, Bakeman R. Explaining disparities in HIV infection among Black and White men who have sex with men: a meta-analysis of HIV risk behaviors. AIDS. 2007;21(15):2083–91. CrossRef
- Vittinghoff E, Douglas J, Judson F, McKirnan D, MacQueen K, Buchbinder SP. Per-contact risk of human immunodeficiency virus transmission between male sexual partners. Am J Epidemiol. 1999;150:306–11. CrossRef
- Royce RA, Seña A, Cates W Jr, Cohen MS. Sexual transmission of HIV. N Engl J Med. 1997;336:1072–8. CrossRef
- Jaffe HW, Valdiserri RO, De Cock KM. The reemerging HIV/AIDS epidemic in men who have sex with men. JAMA. 2007;298:2412–4. CrossRef
- Politch JA, Mayer KH, Welles SL, et al. Highly active antiretroviral therapy does not completely suppress HIV in semen of sexually-active HIV-infected men who have sex with men. AIDS. 2012 (Epub ahead of print).
- Centers for Disease Control and Prevention. Prevalence and awareness of HIV infection among men who have sex with men—21 cities, United States, 2008. MMWR Morb Mortal Wkly Rep. 2010;59:1201–7.
- Sullivan PS, Salazar S, Buchbinder S, Sanchez TH. Estimating the proportion of HIV transmissions from main sex partners among men who have sex with men in five US cities. AIDS. 2009;23(9):1153–62. CrossRef
- Mustanski B, Newcomb ME, Clerkin EM. Relationship characteristics and sexual risk-taking in young men who have sex with men. Health Psychol. 2011;30(5):597–605. CrossRef
- Davidovich U, de Wit JB, Stroebe W. Behavioral and cognitive barriers to safer sex between men in steady relationships: implications for prevention strategies. AIDS Educ Prev. 2004;16(4):304–14. CrossRef
- MacKellar DA, Valleroy LA, Secura GM, Behel S, Bingham T, et al. Unrecognized HIV infection, risk behaviors, and perceptions of risk among young men who have sex with men: opportunities for advancing HIV prevention in the third decade of HIV/AIDS. J Acquir Immune Defic Syndr. 2005;38(5):603–14. CrossRef
- Klitzman R, Exner T, Correale J, Kirshenbaum SB, Remien R, et al. It’s not just what you say: relationships of HIV disclosure and risk reduction among MSM in the post-HAART Era. AIDS Care. 2007;19(6):749–56. CrossRef
- Weinhardt LS, Kelly JA, Brondino MJ, Rotheram-Borus MJ, et al. HIV transmission risk behaviour among men and women living in 4 cities in the United States. J Acquir Immune Defic Syndr. 2004;36:1057–66. CrossRef
- Koblin B, Husnik M, Colfax G, Huang Y, Madison M, et al. Risk factors for HIV infection among men who have sex with men. AIDS. 2006;20:731–9. CrossRef
- Davidovich U, de Wit J, Albrecht N, Geskus R, Stroebe W, Coutinho R. Increase in the share of steady partners as a source of HIV infection: a 17-year study of seroconversion among gay men. AIDS. 2001;15:1303–8. CrossRef
- Epstein H, Morris M. Concurrent partnerships and HIV: an inconvenient truth. J Int AIDS Soc. 2011;14:13. CrossRef
- Morris M. Barking up the wrong evidence tree. Comment on Lurie & Rosenthal, concurrent partnerships as a driver of the HIV epidemic in Sub-Saharan Africa? The evidence is limited. AIDS Behav. 2010;14(1):31–3. CrossRef
- Mah TL, Halperin DT. The evidence for the role of concurrent partnerships in Africa’s HIV epidemics: a response to Lurie and Rosenthal. AIDS Behav. 2010;14:25–8. CrossRef
- Lurie MN, Rosenthal S. The concurrency hypothesis in Sub-Saharan Africa: convincing empirical evidence is still lacking. Response to Mah and Halperin, Epstein, and Morris. AIDS Behav. 2010;14:34–7. CrossRef
- Unexamined Challenges to Applying the Treatment as Prevention Model Among Men Who Have Sex with Men in the United States: A Community Public Health Perspective
AIDS and Behavior
Volume 16, Issue 7 , pp 1739-1742
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